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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ternesten-Hasséus, Ewa Johansson, Ewa-Lena Bende, Mats Millqvist, Eva |
| Description | Country affiliation: Sweden Author Affiliation: Ternesten-Hasséus E ( Asthma and Allergy Research Group, Department of Respiratory Medicine and Allergology, The Sahlgrenska Academy at Göteborg University, Goteborg, Sweden. ewa.ternesten@lungall.gu.se) |
| Abstract | In the absence of other explanations, exercise-induced dyspnea is often labeled as a manifestation of asthma. The aim of this study was to use exercise provocation in cold air among patients with exercise-induced dyspnea, but without any bronchoconstriction, in order to study induced symptoms and different physiological parameters and to measure the possible influence of exercise in cold air on capsaicin cough sensitivity. Eleven patients with exercise-induced dyspnea but no asthma, along with 11 healthy controls, performed a capsaicin inhalation provocation on two occasions. One of these provocations was preceded by an exercise provocation in a cold chamber. Number of coughs, airway symptoms, spirometry, respiratory rate, pulse rate, end-tidal CO(2), and PSaO(2) were registered. During exercise, the patients coughed more than the controls and also had more airway symptoms. After exercise provocation, spirometry values remained unchanged, but capsaicin cough sensitivity was increased and end-tidal CO(2) decreased among the patients, both in comparison to the controls and in comparison to the patients themselves prior to exercise. Exercise-induced dyspnea may be associated with hypocapnia from hyperventilation and increased capsaicin cough sensitivity. The diagnosis of exercise-induced asthma should be questioned when the patient has no signs of bronchoconstriction. |
| File Format | HTM / HTML |
| ISSN | 02770903 |
| Issue Number | 8 |
| Volume Number | 45 |
| e-ISSN | 15324303 |
| Journal | Journal of Asthma |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2008-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pulmonology Asthma Physiopathology Bronchial Hyperreactivity Cold Temperature Adverse Effects Dyspnea Etiology Exercise Physiology Adult Bronchial Provocation Tests Methods Capsaicin Pharmacology Female Forced Expiratory Volume Heart Rate Humans Male Middle Aged Oximetry Respiration Statistics, Nonparametric Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine Immunology and Allergy Pediatrics, Perinatology and Child Health |
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