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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kerwin, Edward M. Nathan, Robert A. Meltzer, Eli O. Ortega, Hector G. Yancey, Steven W. Schoaf, Lynne Dorinsky, Paul M. |
| Description | Country affiliation: United States Author Affiliation: Kerwin EM ( Clinical Research Institute of Southern Oregon, Medford, OR 97504, USA. ekerwin@allergyasthmaso.com) |
| Abstract | BACKGROUND: The twice daily administration of an inhaled corticosteroid (ICS) and long-acting beta(2)-agonist (LABA) has been shown to be effective in achieving asthma control. The once daily administration of an ICS/LABA may be a treatment option for some patients. OBJECTIVE: To assess the effectiveness of fluticasone propionate (FP)/salmeterol via a single inhaler (FSC) administered once daily compared with FP once daily, FSC twice daily, or placebo. METHODS: A 12-week, randomized, double-blind multicenter study conducted in 844 patients > or = 12 years of age who were symptomatic while using a short-acting beta(2)-agonist alone. Blinded treatments included: FSC 250/50 mcg once daily in the evening (FSC 250/50 QD), FP 250 mcg once daily in the evening (FP 250 QD), FSC 100/50 mcg twice daily (FSC 100/50 mcg BID), or placebo. All treatments were delivered via the Diskus device. RESULTS: All treatments demonstrated greater improvements in efficacy measures compared with placebo. Overall, the greatest improvements were observed in the patients receiving FSC, either once or twice daily, compared with the FP 250 QD group. The two FSC treatments were similar except that QD dosing did not maintain improvements in lung function for 24h compared with twice daily dosing. All treatments were well tolerated. No suppression of HPA axis, as assessed by 24-h urinary cortisol excretion, was observed in any of the active treatment groups. CONCLUSION: In patients symptomatic on a short-acting beta(2)-agonist alone, FSC 100/50 mcg BID was shown to provide better efficacy than a higher strength (FSC 250/50 mcg) administered once daily. However, a once daily regimen was effective and may be a valuable treatment option for some patients. Registered at (http://ctr.gsk.co.uk/welcome.asp) (SAS30022). |
| File Format | HTM / HTML |
| ISSN | 09546111 |
| Issue Number | 4 |
| Volume Number | 102 |
| e-ISSN | 15323064 |
| Journal | Respiratory Medicine |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pulmonary Medicine Albuterol Analogs & Derivatives Androstadienes Administration & Dosage Anti-asthmatic Agents Asthma Drug Therapy Administration, Inhalation Adolescent Adult Aged Aged, 80 And Over Therapeutic Use Physiopathology Child Drug Administration Schedule Drug Therapy, Combination Female Fluticasone Forced Expiratory Volume Humans Lung Male Metered Dose Inhalers Middle Aged Peak Expiratory Flow Rate Safety Salmeterol Xinafoate Treatment Outcome Comparative Study Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine |
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