NDLI: Identification of a novel CCR7 gene in rainbow trout with differential expression in the context of mucosal or systemic infection.

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Identification of a novel CCR7 gene in rainbow trout with differential expression in the context of mucosal or systemic infection.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ordás, M. Camino Castro, Rosario Dixon, Brian Sunyer, J. Oriol Bjork, Sarah Bartholomew, Jerri Korytar, Tomas Köllner, Bernd Cuesta, Alberto Tafalla, Carolina
Description	Country affiliation: Spain Author Affiliation: Ordás MC ( Centro de Investigación en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain.)
Abstract	In mammals, CCR7 is the chemokine receptor for the CCL19 and CCL21 chemokines, molecules with a major role in the recruitment of lymphocytes to lymph nodes and Peyer's patches in the intestinal mucosa, especially naïve T lymphocytes. In the current work, we have identified a CCR7 orthologue in rainbow trout (Oncorhynchus mykiss) that shares many of the conserved features of mammalian CCR7. The receptor is constitutively transcribed in the gills, hindgut, spleen, thymus and gonad. When leukocyte populations were isolated, IgM(+) cells, T cells and myeloid cells from head kidney transcribed the CCR7 gene. In blood, both IgM(+) and IgT(+) B cells and myeloid cells but not T lymphocytes were transcribing CCR7, whereas in the spleen, CCR7 mRNA expression was strongly detected in T lymphocytes. In response to infection with viral hemorrhagic septicemia virus (VHSV), CCR7 transcription was down-regulated in spleen and head kidney upon intraperitoneal infection, whereas upon bath infection, CCR7 was up-regulated in gills but remained undetected in the fin bases, the main site of virus entry. Concerning its regulation in the intestinal mucosa, the ex vivo stimulation of hindgut segments with Poly I:C or inactivated bacteria significantly increased CCR7 transcription, while in the context of an infection with Ceratomyxa shasta, the levels of transcription of CCR7 in both IgM(+) and IgT(+) cells from the gut were dramatically increased. All these data suggest that CCR7 plays an important role in lymphocyte trafficking during rainbow trout infections, in which CCR7 appears to be implicated in the recruitment of B lymphocytes into the gut.
File Format	HTM / HTML
ISSN	0145305X
e-ISSN	18790089
DOI	10.1016/j.dci.2012.07.001
Journal	Developmental & Comparative Immunology
Issue Number	2
Volume Number	38
Language	English
Publisher	Elsevier
Publisher Date	2012-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology Fish Proteins Genetics Novirhabdovirus Oncorhynchus Mykiss Immunology Receptors, Ccr7 Animals Fish Diseases Gastrointestinal Tract Leukocytes Mucous Membrane Myxozoa Organ Specificity Parasitic Diseases, Animal Phylogeny Rhabdoviridae Infections Veterinary Transcriptome Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Developmental Biology Immunology

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Viral haemorrhagic septicaemia virus IVb experimental infection of rainbow trout, Oncorhynchus mykiss (Walbaum), and fathead minnow, Pimphales promelas (Rafinesque).

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PAMP induced expression of immune relevant genes in head kidney leukocytes of rainbow trout (Oncorhynchus mykiss).

Antibody response of rainbow trout with single or double infections involving viral haemorrhagic septicaemia virus and infectious haematopoietic necrosis virus.

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Isolation of bacterial probiotic candidates from the gastrointestinal tract of rainbow trout, Oncorhynchus mykiss (Walbaum), and screening for inhibitory activity against Flavobacterium psychrophilum.

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Rainbow trout surviving infections of viral haemorrhagic septicemia virus (VHSV) show lasting antibodies to recombinant G protein fragments.

Identification of a novel CCR7 gene in rainbow trout with differential expression in the context of mucosal or systemic infection.

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Identification of a novel CCR7 gene in rainbow trout with differential expression in the context of mucosal or systemic infection.