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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ruwanpathirana, Thilanga Owen, Alice Renzaho, Andre M. N. Zomer, Ella Gambhir, Manoj Reid, Christopher M. |
| Spatial Coverage | Australia |
| Description | Country affiliation: Australia Author Affiliation: Ruwanpathirana T ( CCRE Therapeutics, The Alfred Centre, Melbourne, Vic., Australia.); Owen A ( CCRE Therapeutics, The Alfred Centre, Melbourne, Vic., Australia.); Renzaho AM ( Epidemiological Modelling Unit, Department of Epidemiology and Preventive Medicine, The Alfred Centre, Melbourne, Vic., Australia.); Zomer E ( Centre for International Health, Department of Epidemiology and Preventive Medicine, Burnet Institute, Monash University, Melbourne, Vic., Australia.); Gambhir M ( School of Public Health, Curtin University, Perth, WA, Australia.); Reid CM ( CCRE Therapeutics, The Alfred Centre, Melbourne, Vic., Australia.) |
| Abstract | The study was designed to model the effectiveness and cost effectiveness of oral Vitamin D supplementation as a primary prevention strategy for cardiovascular disease among a migrant population in Australia. It was carried out in the Community Health Service, Kensington, Melbourne. Best-case scenario analysis using a Markov model was employed to look at the health care providers' perspective. Adult migrants who were vitamin D deficient and free from cardiovascular disease visiting the medical centre at least once during the period from 1 January 2010 to 31 December 2012 were included in the study. The blood pressure-lowering effect of vitamin D was taken from a published meta-analysis and applied in the Framingham 10 year cardiovascular risk algorithm (with and without oral vitamin D supplements) to generate the probabilities of cardiovascular events. A Markov decision model was used to estimate the provider costs associated with the events and treatments. Uncertainties were derived by Monte Carlo simulation. Vitamin D oral supplementation (1000 IU/day) for 10 years could potentially prevent 31 (interquartile range (IQR) 26 to 37) non-fatal and 11 (IQR 10 to 15) fatal cardiovascular events in a migrant population of 10,000 assuming 100% compliance. The provider perspective incremental cost effectiveness per year of life saved was AU\$3,992 (IQR 583 to 8558). This study suggests subsidised supplementation of oral vitamin D may be a cost effective intervention to reduce non-fatal and fatal cardiovascular outcomes in high-risk migrant populations. |
| File Format | HTM / HTML |
| ISSN | 03051870 |
| Issue Number | 6 |
| Volume Number | 42 |
| e-ISSN | 14401681 |
| Journal | Clinical and Experimental Pharmacology and Physiology |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2015-06-01 |
| Publisher Place | Australia |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Physiology Discipline Pharmacology Cardiovascular Diseases Ethnology Prevention & Control Community Health Services Dietary Supplements Transients And Migrants Vitamin D Administration & Dosage Administration, Oral Adult Aged Australia Blood Methods Female Humans Male Markov Chains Middle Aged Risk Factors Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) Pharmacology |
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