NDLI: The role of Krüppel-like factor 4 in transforming growth factor-ß-induced inflammatory and fibrotic responses in human proximal tubule cells.

Please wait, while we are loading the content...

Associations of glycated haemoglobin A1c and glycated albumin with subclinical atherosclerosis in middle-aged and elderly Chinese population with impaired glucose regulation.

Pharmacological evidence that $5-HT_{1D}$ activation induces renal vasodilation by NO pathway in rats

Role of Peptide YY in blood vessel function and atherosclerosis in a rabbit model.

Can oral vitamin D prevent the cardiovascular diseases among migrants in Australia? Provider perspective using Markov modelling.

Effects of performing electrocardio-graphy in the community on overall coronary artery ischemia time in patients with acute myocardial infarction.

Impact of high lipoprotein(a) levels on in-stent restenosis and long-term clinical outcomes of angina pectoris patients undergoing percutaneous coronary intervention with drug-eluting stents in Asian population.

Renoprotective effect of berberine on type 2 diabetic nephropathy in rats.

Telmisartan attenuates peritoneal fibrosis via peroxisome proliferator-activated receptor-Î³ activation in rats.

Methamphetamine induces DNA damage in specific regions of the female rat brain.

Pharmacological characterization of mechanisms involved in the vasorelaxation produced by rosuvastatin in aortic rings from rats with a cafeteria-style diet

Increased brain L-arginine availability facilitates cutaneous heat loss induced by running exercise.

Increased cardiovascular risk without generalized arterial dilating diathesis in persons who do not have abdominal aortic aneurysm but who are first-degree relatives of abdominal aortic aneurysm patients.

The role of Krüppel-like factor 4 in transforming growth factor-ß-induced inflammatory and fibrotic responses in human proximal tubule cells.

Quantitative tissue velocity imaging evaluation of ventricular function in obstructive sleep apnoea-hypopnoea syndrome in children.

Vitamin D3 potentiates the growth inhibitory effects of metformin in DU145 human prostate cancer cells mediated by AMPK/mTOR signalling pathway.

Selective blockade of mGlu5 metabotropic glutamate receptors is protective against hepatic mitochondrial dysfunction in 6-OHDA lesioned Parkinsonian rats.

Pubertal administration of antiserum against nerve growth factor regresses renal vascular remodeling in spontaneously hypertensive rats.

Lycopene inhibits cyclic strain-induced endothelin-1 expression through the suppression of reactive oxygen species generation and induction of heme oxygenase-1 in human umbilical vein endothelial cells.

Stressed SIRT7: facing a crossroad of senescence and immortality.

Year: 2015 Volume: 42 Issue: 5

Year: 2015 Volume: 42 Issue: 4

Year: 2015 Volume: 42 Issue: 3

Year: 2015 Volume: 42 Issue: 2

Year: 2015 Volume: 42 Issue: 1

Year: 2014 Volume: 41

Year: 2013 Volume: 40

Year: 2012 Volume: 39

Year: 2011 Volume: 38

Year: 2010 Volume: 37

Year: 2009 Volume: 36

Year: 2008 Volume: 35

Year: 1996 Volume: 23

The role of Krüppel-like factor 4 in transforming growth factor-ß-induced inflammatory and fibrotic responses in human proximal tubule cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mreich, Ellein Chen, Xin-Ming Zaky, Amgad Pollock, Carol A. Saad, Sonia
Description	Country affiliation: Australia Author Affiliation: Mreich E ( Department of Medicine, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St Leonards, NSW, Australia.); Chen XM ( Department of Medicine, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St Leonards, NSW, Australia.); Zaky A ( Department of Medicine, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St Leonards, NSW, Australia.); Pollock CA ( Department of Medicine, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St Leonards, NSW, Australia.); Saad S ( Department of Medicine, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St Leonards, NSW, Australia.)
Abstract	Krüppel-like factor 4 (KLF4) is known to mitigate inflammation in several cell types. Using human proximal tubule cells, the present study aimed to investigate the role of KLF4 in regulating transforming growth factor (TGF)-ß1 induced inflammatory and fibrotic responses. Human kidney proximal tubular cells were exposed to high glucose, or TGF-ß1 and KLF4 expressions were determined. Cells were then transfected with empty vector or KLF4 and exposed to 2-ng/mL TGF-ß1 for up to 72 h. Inflammatory proteins (macrophage migration inhibitory factor and monocyte chemoattractant protein-1) and pro-fibrotic proteins (fibronectin and collagen IV) were measured after 72 h by enzyme-linked immunosorbent assay and western blot, respectively. To determine the relevance to in vivo models of chronic kidney disease, KLF4 protein expression in streptozotocin-induced diabetic mice was determined. Krüppel-like factor 4 messenger RNA (mRNA) levels were significantly reduced in high glucose-treated human kidney proximal tubular cells. High glucose increased TGF-ß1 mRNA expression, which significantly increased migration inhibitory factor and monocyte chemoattractant protein-1 protein secretion. Transforming growth factor-ß1 significantly increased fibronectin and collagen IV protein expression. The overexpression of KLF4 significantly reduced TGF-ß-mediated increases in migration inhibitory factor and monocyte chemoattractant protein-1 but had no effect on TGF-ß-mediated fibronectin and collagen IV mRNA and protein expression. The levels of KLF4 mRNA were significantly reduced in the diabetic kidney, and diabetic animals had a significant reduction in renal tubular expression of KLF4 proteins. This data suggest that KLF4 reduces inflammation induced by TGF-ß1, suggesting a therapeutic role for KLF4 in diabetic nephropathy.
File Format	HTM / HTML
ISSN	03051870
Issue Number	6
Volume Number	42
e-ISSN	14401681
Journal	Clinical and Experimental Pharmacology and Physiology
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2015-06-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Physiology Discipline Pharmacology Diabetes Mellitus, Experimental Chemically Induced Metabolism Kidney Tubules, Proximal Kruppel-like Transcription Factors Physiology Transforming Growth Factor Beta1 Toxicity Animals Cells, Cultured Pathology Fibrosis Humans Inflammation Mediators Drug Effects Mice Mice, Knockout Journal Article
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Pharmacology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Role of Kruppel-like factor 6 in transforming growth factor-beta1-induced epithelial-mesenchymal transition of proximal tubule cells.

Increased expression of p21WAF1/CIP1 in kidney proximal tubules mediates fibrosis.

Krüppel-like factor KLF10 regulates transforming growth factor receptor II expression and TGF-ß signaling in CD8+ T lymphocytes.

Role of Krüppel-like factor 6 in transforming growth factor-β1-induced epithelial-mesenchymal transition of proximal tubule cells

Progressive histone alterations and proinflammatory gene activation: consequences of heme protein/iron-mediated proximal tubule injury

TGF-beta1/Smad7 signaling stimulates renal tubulointerstitial fibrosis induced by AAI.

Heme oxygenase-1 deficiency promotes epithelial-mesenchymal transition and renal fibrosis.

Latent transforming growth factor-beta-binding protein-4 regulates transforming growth factor-beta1 bioavailability for activation by fibrogenic lung fibroblasts in response to bleomycin.

Glucocorticoid enhances hypoxia- and/or transforming growth factor-ß-induced plasminogen activator inhibitor-1 production in human proximal renal tubular cells.

The role of Krüppel-like factor 4 in transforming growth factor-ß-induced inflammatory and fibrotic responses in human proximal tubule cells.

Similar Documents

Role of Kruppel-like factor 6 in transforming growth factor-beta1-induced epithelial-mesenchymal transition of proximal tubule cells.

Increased expression of p21WAF1/CIP1 in kidney proximal tubules mediates fibrosis.

Krüppel-like factor KLF10 regulates transforming growth factor receptor II expression and TGF-ß signaling in CD8+ T lymphocytes.

Role of Krüppel-like factor 6 in transforming growth factor-β1-induced epithelial-mesenchymal transition of proximal tubule cells

Progressive histone alterations and proinflammatory gene activation: consequences of heme protein/iron-mediated proximal tubule injury

TGF-beta1/Smad7 signaling stimulates renal tubulointerstitial fibrosis induced by AAI.

Heme oxygenase-1 deficiency promotes epithelial-mesenchymal transition and renal fibrosis.

Latent transforming growth factor-beta-binding protein-4 regulates transforming growth factor-beta1 bioavailability for activation by fibrogenic lung fibroblasts in response to bleomycin.

Glucocorticoid enhances hypoxia- and/or transforming growth factor-ß-induced plasminogen activator inhibitor-1 production in human proximal renal tubular cells.

The role of Krüppel-like factor 4 in transforming growth factor-ß-induced inflammatory and fibrotic responses in human proximal tubule cells.