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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cashman, Kevin D. |
| Description | Country affiliation: Ireland Author Affiliation: Cashman KD ( Vitamin D Research Group, School of Food and Nutritional Sciences, and Department of Medicine, University College Cork, Cork, Ireland.) |
| Abstract | Beyond the well-accepted effects on the skeleton, low vitamin D status has been linked to increased risk of several non-skeletal disease, including CVD. If low serum 25-hydroxyvitamin D (25(OH)D) concentration is causally linked to risk of CVD then this is important not only because low vitamin D status is quite common particularly in winter in countries above 40°N, but also of key relevance is the fact that such low vitamin D status can be improved by food-based strategies. The overarching aim of the present paper is to review the current evidence-base to support a link between low vitamin D status and CVD risk. The review initially briefly overviews how mechanistically vitamin D may play a role in CVD and then reviews the current available evidence-base to support a link between low vitamin D status and CVD risk, with particular emphasis on data from the randomised control trials, cohort studies and recent meta-analysis data as well as to the conclusions of a number of authoritative agencies/bodies. Finally, the review summarises current serum 25(OH)D concentrations within a select number of adult populations in the context of different definitions of vitamin D status proposed recently, and then briefly highlights food-based strategies for increasing vitamin D intake and status. In conclusion, at present the data for a causal link between low vitamin D status and CVD are mixed and ambiguous; however, should causality be affirmed by ongoing and future studies, there are food-based strategies for enhanced vitamin D status in the population which could ultimately lower risk of CVD. |
| File Format | HTM / HTML |
| ISSN | 00296651 |
| e-ISSN | 14752719 |
| Journal | Proceedings of the Nutrition Society |
| Issue Number | 1 |
| Volume Number | 73 |
| Language | English |
| Publisher | Cambridge University Press |
| Publisher Date | 2014-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Nutritional Sciences Cardiovascular Diseases Etiology Nutritional Status Vitamin D Deficiency Complications Vitamin D Therapeutic Use Vitamins Blood Prevention & Control Diet Dietary Supplements Administration & Dosage Analogs & Derivatives |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Medicine |
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