NDLI: Telmisartan attenuates peritoneal fibrosis via peroxisome proliferator-activated receptor-Î³ activation in rats.

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Telmisartan attenuates peritoneal fibrosis via peroxisome proliferator-activated receptor-Î³ activation in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Su, Xuesong Yu, Rui Yang, Xu Zhou, Guangyu Wang, Yanqiu Li, Li Li, Detian
Description	Country affiliation: China Author Affiliation: Su X ( Department of Nephrology, Shengjing Hospital of China Medical University, Shenyang, China.); Yu R ( Department of Nephrology, Shengjing Hospital of China Medical University, Shenyang, China.); Yang X ( Department of Nephrology, Shengjing Hospital of China Medical University, Shenyang, China.); Zhou G ( Department of Nephrology, Shengjing Hospital of China Medical University, Shenyang, China.); Wang Y ( Department of Nephrology, Shengjing Hospital of China Medical University, Shenyang, China.); Li L ( Department of Nephrology, Shengjing Hospital of China Medical University, Shenyang, China.); Li D ( Department of Nephrology, Shengjing Hospital of China Medical University, Shenyang, China.)
Abstract	Peritoneal dialysis (PD) is an effective treatment for patients with end-stage renal diseases, but long-term continuous PD causes peritoneal fibrosis (PF). This study aims to evaluate the anti-fibrotic effect of telmisartan on a rat model of PF and to investigate the underlying mechanisms. Five-sixths kidney nephrectomy and PD were used to establish the PF rat model. Glucose (2.5%) was used to establish an in vitro model in rat peritoneal mesothelial cells (PMC). Haematoxylin-eosin staining was used to examine the structural alterations. Masson's trichrome staining was used to observe the tissue fibrosis in peritoneal membrane of rats. Real-time polymerase chain reaction was used to measure messenger RNA expressions of profibrotic factors. Western blotting was used to determine protein expressions of profibrotic factors, peroxisome proliferator-activated receptor-Î³, and mitogen-activated protein kinases (MAPK). Results demonstrated that administration of telmisartan dose-dependently attenuated the thickening of the peritoneal membrane and the fibrosis induced by long-term PD fluid exposure in rats. In addition, telmisartan treatment inhibited the upregulation of profibrotic factors induced by PD in the peritoneum of rats and by high-concentration glucose in PMC. Telmisartan was also effective in inhibiting PD and high-concentration, glucose-induced phosphorylation of MAPK in the peritoneum and PMC. Furthermore, peroxisome proliferator-activated receptor-Î³ (PPARÎ³) inhibitor GW9662 blocked these protective effects of telmisartan in PMC. The results suggest that telmisartan is effective in attenuating PD-induced PF, and this effect may be associated with the inhibition of profibrotic factor expression and MAPK phosphorylation via PPARÎ³ activation.
File Format	HTM / HTML
ISSN	03051870
Issue Number	6
Volume Number	42
e-ISSN	14401681
Journal	Clinical and Experimental Pharmacology and Physiology
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2015-06-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Physiology Discipline Pharmacology Angiotensin Ii Type 1 Receptor Blockers Therapeutic Use Benzimidazoles Benzoates Ppar Gamma Metabolism Peritoneal Fibrosis Prevention & Control Animals Cells, Cultured Dose-response Relationship, Drug Male Antagonists & Inhibitors Pathology Rats Rats, Sprague-dawley Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Pharmacology

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