NDLI: Fabrication of blended polycaprolactone/poly(lactic-co-glycolic acid)/ß-tricalcium phosphate thin membrane using solid freeform fabrication technology for guided bone regeneration.

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Fabrication of blended polycaprolactone/poly(lactic-co-glycolic acid)/ß-tricalcium phosphate thin membrane using solid freeform fabrication technology for guided bone regeneration.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shim, Jin-Hyung Huh, Jung-Bo Park, Ju Young Jeon, Young-Chan Kang, Seong Soo Kim, Jong Young Rhie, Jong-Won Cho, Dong-Woo
Description	Author Affiliation: Shim JH ( Department of Mechanical Engineering, POSTECH, Gyeongbuk, Korea.)
Abstract	This study developed a bioabsorbable-guided bone regeneration membrane made of blended polycaprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA), and beta-tricalcium phosphate (ß-TCP) using solid freeform fabrication (SFF) technology. The chemical and physical properties of the membrane were evaluated using field emission scanning electron microscopy, energy dispersive spectroscopy, and a tensile test. In vitro cell activity assays revealed that the adhesion, proliferation, and osteogenic differentiation of seeded adipose-derived stem cells (ADSCs) were significantly promoted by the PCL/PLGA/ß-TCP membranes compared with PCL/PLGA membranes. When the PCL/PLGA and PCL/PLGA/ß-TCP membranes were implanted on rabbit calvaria bone defects without ADSCs, microcomputed tomography and histological analyses confirmed that the SFF-based PCL/PLGA/ß-TCP membranes greatly increased bone formation without the need for bone substitute materials. Moreover, tight integration, which helps to prevent exposure of the membrane, between both membranes and the soft tissues was clearly observed histologically. The SFF-based PCL/PLGA and PCL/PLGA/ß-TCP membranes retained their mechanical stability for up to 8 weeks without significant collapse. Furthermore, PCL/PLGA/ß-TCP underwent adequate degradation without a significant immune response at 8 weeks.
File Format	HTM / HTML
ISSN	21524947
e-ISSN	21524955
DOI	10.1089/ten.TEA.2011.0730
Journal	Tissue Engineering Part A
Issue Number	3-4
Volume Number	19
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2013-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Biotechnology Bone Regeneration Physiology Calcium Phosphates Chemistry Guided Tissue Regeneration Instrumentation Lactic Acid Membranes, Artificial Polyesters Polyglycolic Acid Skull Fractures Surgery Animals Biocompatible Materials Chemical Synthesis Equipment Design Equipment Failure Analysis Fracture Healing Materials Testing Rabbits Diagnosis Tissue Scaffolds Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article

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Fabrication of blended polycaprolactone/poly(lactic-co-glycolic acid)/β-tricalcium phosphate thin membrane using solid freeform fabrication technology for guided bone regeneration.

Stimulation of healing within a rabbit calvarial defect by a PCL/PLGA scaffold blended with TCP using solid freeform fabrication technology.

Fabrication of Blended Polycaprolactone/Poly (Lactic-Co-Glycolic Acid)/β-Tricalcium Phosphate Thin Membrane Using Solid Freeform Fabrication Technology for Guided Bone Regeneration

Coating of ß-tricalcium phosphate scaffolds-a comparison between graphene oxide and poly-lactic-co-glycolic acid.

Osteoconductive properties of ß-tricalcium phosphate matrix, polylactic and polyglycolic acid gel, and calcium phosphate cement in bone defects.

Role of platelet gel and calcium-coated Lactosorb membranes in healing critical calvarial defects.

Effects of a chitosan membrane coated with polylactic and polyglycolic acid on bone regeneration in a rat calvarial defect.

Polypyrrole coating on poly-(lactide/glycolide)-ß-tricalcium phosphate screws enhances new bone formation in rabbits.

Fabrication of 3D Printed Poly(lactic acid)/Polycaprolactone Scaffolds Using TGF-β1 for Promoting Bone Regeneration

Fabrication of blended polycaprolactone/poly(lactic-co-glycolic acid)/ß-tricalcium phosphate thin membrane using solid freeform fabrication technology for guided bone regeneration.

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