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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yoon, Kyung-Ae Cho, Hye-Sim Shin, Hong-In Cho, Je-Yoel |
| Description | Author Affiliation: Yoon KA ( Department of Oral Pathology, School of Dentistry, IHBR, Kyungpook National University, Daegu, Korea.) |
| Abstract | Stem cell maintenance requires a specific microenvironment. Hematopoietic stem cells (HSCs) are mainly maintained by the endosteal osteoblast (OB) niche, which provides a quiescent HSC microenvironment, and the vascular niche, which regulates the proliferation, differentiation, and mobilization of HSCs. The systemic administration of FGF2 failed to induce normal hematopoiesis in bone marrow (BM) by reducing SDF-1, an important factor for hematopoiesis. Interestingly, SDF-1 levels were decreased in the OBs, but increased in vascular endothelial C166 cells when FGF2 was administered. We hypothesized that FGF2 induces changes in HSC migration from BM; therefore, we investigated FGF2-induced factors of HSC migration by a microarray chip. We searched the genes that were decreased in primary OBs, but increased in C166 cells upon FGF2 treatment. We confirmed selected genes that function in the extracellular region and identified the CXCR2-related chemokine candidate LIX/Cxcl5. A chemotaxis assay showed that CXCL5 induced the migration of HSCs (CD34(-/low)LSK). Our data suggest that the differential regulation of the chemokine CXCL5 between OBs and endothelial cells upon FGF2 treatment is involved in HSC mobilization from the OB niche or BM to peripheral blood. |
| File Format | HTM / HTML |
| ISSN | 15473287 |
| e-ISSN | 15578534 |
| DOI | 10.1089/scd.2012.0128 |
| Journal | Stem Cells and Development |
| Issue Number | 18 |
| Volume Number | 21 |
| Language | English |
| Publisher | Mary Ann Liebert, Inc. |
| Publisher Date | 2012-12-10 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Cell Biology Discipline Hematology Chemokine Cxcl5 Metabolism Endothelial Cells Fibroblast Growth Factor 2 Pharmacology Hematopoietic Stem Cells Osteoblasts Animals Bone Marrow Bone Marrow Cells Cytology Cell Differentiation Cell Line Cell Movement Chemokine Cxcl12 Biosynthesis Gene Expression Regulation Hematopoiesis Drug Effects Mice Stem Cell Niche |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology Hematology |
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