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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lau, Kit-Man Wong, Jack Ho Wu, Yu-On Cheng, Ling Wong, Chun-Wai To, Ming-Ho Lau, Ching-Po Yew, David Tai-Wai Leung, Ping-Chung Fung, Kwok-Pui Hui, Mamie Ng, Tzi-Bun Lau, Clara Bik-San |
| Description | Country affiliation: China Author Affiliation: Lau KM ( Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China); Wong JH ( School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China); Wu YO ( Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China); Cheng L ( Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China); Wong CW ( Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China); To MH ( Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China); Lau CP ( Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China); Yew DT ( Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China); Leung PC ( Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China); Fung KP ( Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China); Hui M ( Department of Microbiology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.); Ng TB ( School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China); Lau CB ( Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China) |
| Abstract | Bakuchiol was an active antifungal compound isolated from Psoraleae Fructus by means of bioassay-guided fractionation in our previous study. The present work aimed to investigate the underlying mechanisms and the therapeutic effect of bakuchiol in Trichophyton mentagrophytes-induced tinea pedis. After exposure to bakuchiol at 0.25-fold, 0.5-fold and 1-fold of minimum inhibitory concentration (MIC) (3.91 µg/ml) for 24h, the fungal conidia of T. mentagrophytes demonstrated a significant dose-dependent increase in membrane permeability. Moreover, bakuchiol at 1-fold MIC elicited a 187% elevation in reactive oxygen species (ROS) level in fungal cells after a 3-h incubation. However, bakuchiol did not induce DNA fragmentation. In a guinea pig model of tinea pedis, bakuchiol at 1%, 5% or 10% (w/w) concentration in aqueous cream could significantly reduce the fungal burden of infected feet (p<0.01-0.05). In conclusion, this is the first report to demonstrate that bakuchiol is effective in relieving tinea pedis and in inhibiting the growth of the dermatophyte T. mentagrophytes by increasing fungal membrane permeability and ROS generation, but not via induction of DNA fragmentation. |
| File Format | HTM / HTML |
| ISSN | 09447113 |
| Issue Number | 7 |
| Volume Number | 21 |
| e-ISSN | 1618095X |
| Journal | Phytomedicine |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-06-15 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Complementary Therapies Phenols Pharmacology Tinea Pedis Drug Therapy Trichophyton Drug Effects Animals Antifungal Agents Cell Membrane Permeability Dna Fragmentation Disease Models, Animal Dose-response Relationship, Drug Female Guinea Pigs Microbial Sensitivity Tests Reactive Oxygen Species Metabolism Microbiology Pathogenicity Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science |
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