NDLI: Selective monoamine oxidase B inhibition by an Aphanizomenon flos-aquae extract and by its constitutive active principles phycocyanin and mycosporine-like amino acids.

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Selective monoamine oxidase B inhibition by an Aphanizomenon flos-aquae extract and by its constitutive active principles phycocyanin and mycosporine-like amino acids.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Scoglio, Stefano Benedetti, Yanina Benvenuti, Francesca Battistelli, Serafina Canestrari, Franco Benedetti, Serena
Description	Author Affiliation: Scoglio S ( Centro di Ricerche Nutriterapiche, via I Maggetti 14, 61029 Urbino, Italy. Electronic address: stefanoscoglio@me.com.); Benedetti Y ( Centro di Ricerche Nutriterapiche, via I Maggetti 14, 61029 Urbino, Italy); Benvenuti F ( Dipartimento di Scienze Biomolecolari, Sezione di Biochimica Clinica e Biologia Cellulare, Università di Urbino 'Carlo Bo', via Ubaldini 7, 61029 Urbino, Italy.); Battistelli S ( Dipartimento di Scienze Biomolecolari, Sezione di Biochimica Clinica e Biologia Cellulare, Università di Urbino 'Carlo Bo', via Ubaldini 7, 61029 Urbino, Italy.); Canestrari F ( Dipartimento di Scienze Biomolecolari, Sezione di Biochimica Clinica e Biologia Cellulare, Università di Urbino 'Carlo Bo', via Ubaldini 7, 61029 Urbino, Italy.); Benedetti S ( Dipartimento di Scienze Biomolecolari, Sezione di Biochimica Clinica e Biologia Cellulare, Università di Urbino 'Carlo Bo', via Ubaldini 7, 61029 Urbino, Italy.)
Abstract	Aphanizomenon flos-aquae (AFA) is a fresh water unicellular blue-green alga that has been traditionally used for over 25 years for its health-enhancing properties. Recent studies have shown the ability of a proprietary AFA extract (Klamin(®)) to improve mood, counteract anxiety, and enhance attention and learning. Aim of this study was to test the monoamine oxidase (MAO) inhibition activity of the same AFA extract and of its constituents phycocyanin (AFA-PC) and mycosporine-like aminoacids (AFA-MAAs). All compounds showed a dose-dependent selective inhibition of MAO-B activity as compared to MAO-A. The IC50 values of the AFA extract (concentration 10 mg/ml), AFA-PC and AFA-MAAs were 6.4 µl/ml, 1.33 µM and 1.98 µM, respectively, evidencing a mixed-type of inhibition for the AFA extract (Ki 0.99 µl/ml), a non-competitive inhibition for AFA-PC (Ki 1.06 µM) and a competitive inhibition for AFA-MAAs (Ki 0.585 µM). These results are important to explain the neuromodulating properties of the AFA extract Klamin(®), which is rich in phenylethylamine, a general neuromodulator, that would nevertheless rapidly destroyed by MAO-B enzymes without the inhibitory activity of the synergic active principles AFA-PC and AFA-MAAs. The present investigation thus proposes the extract as potentially relevant in clinical areas such as mood disorders and neurodegenerative diseases.
File Format	HTM / HTML
ISSN	09447113
Issue Number	7
Volume Number	21
e-ISSN	1618095X
Journal	Phytomedicine
Language	English
Publisher	Elsevier
Publisher Date	2014-06-15
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Complementary Therapies Amino Acids Chemistry Pharmacology Aphanizomenon Monoamine Oxidase Inhibitors Phycocyanin Plant Extracts Drug Evaluation, Preclinical Methods Inhibitory Concentration 50 Monoamine Oxidase Metabolism Journal Article
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science

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