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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Uddin, Ghias Rauf, Abdur Siddiqui, Bina S. Muhammad, Naveed Khan, Ajmal Shah, Syed Uzair Ali |
| Description | Author Affiliation: Uddin G ( Institute of Chemical Sciences, University of Peshawar, Peshawar 25120, KPK, Pakistan. Electronic address: ghiasuddin@upesh.edu.pk.); Rauf A ( Institute of Chemical Sciences, University of Peshawar, Peshawar 25120, KPK, Pakistan.); Siddiqui BS ( H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.); Muhammad N ( Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan.); Khan A ( H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.); Shah SU ( H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.) |
| Abstract | Diospyros lotus L. is traditionally used in various diseases including pain and sleep disorders. The pain and inflammation are the common problems, which are treated with various synthetic analgesic drugs, and associated the side effects. The natural products have gained significant importance over synthetic drugs. The importance of phyto-medicine the current study has been designed with the aim to investigate the analgesic and anti-inflammatory effects of Diospyros lotus and bioassay guided isolation from its crude fractions. Seven known compounds; lupeol (1), 7-methyljuglone (2), ß-Sitosterol (3), stigmasterol (4) betulinic acid (5), diospyrin (6; DS) and 8-hydroxyisodiospyrin (7; HDS) which were hitherto unreported from D. lotus. The chloroform fraction (CFDL) and isolated compounds DS and HDS were evaluated for anti-nociceptive, sedative and anti-inflammatory effects. The acetic acid induced writing was significantly (p<0.001) protected by CFDL (72.43%), DS (40.87%) and HDS (65.76%) at higher doses which exhibited peripheral and central analgesic effects in acetic acid and hot-plat pain paradigms. Regarding the anti-inflammatory effect the CFDL (77.43%), DS (80.54%) and HDS (75.87%) protected the carrageenan paw edema after 3rd h. The central analgesic effect was significantly antagonized with naloxone (0.5 mg/kg), showing opiodergic mechanism of action. The CFDL, DS and HDS were also proved sedative in open field animal models. In acute toxicity study the chloroform fraction [CFDL (50, 100 and 150 mg/kg)], DS (5 and 10 mg/kg) and HDS (5 and 10 mg/kg) were found safe. Our study concluded that CFDL, DS and HDS have marked anti-nociceptive, anti-inflammatory and sedative effect. The anti-nociceptive and anti-inflammatory effects of the roots of D. lotus are partially attributed due to the presence of analgesic constituents like diospyrin (DS), 8-hydroxyisodiospyrin (HDS) and strongly supports the ethno-pharmacological uses of D. lotus as anti-nociceptive, anti-inflammatory and sedative. |
| File Format | HTM / HTML |
| ISSN | 09447113 |
| Issue Number | 7 |
| Volume Number | 21 |
| e-ISSN | 1618095X |
| Journal | Phytomedicine |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-06-15 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Complementary Therapies Analgesics Pharmacology Anti-inflammatory Agents Diospyros Chemistry Hypnotics And Sedatives Plant Extracts Acetic Acid Adverse Effects Animals Carrageenan Toxicity Chloroform Drug Evaluation, Preclinical Methods Edema Chemically Induced Drug Therapy Female Male Mice, Inbred Balb C Naphthoquinones Isolation & Purification Toxicity Tests, Acute Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science |
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