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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bartoletti, Maria Colantoni, Alessia De Luca, Valentina Gaiardi, Margherita |
| Description | Country affiliation: Italy Author Affiliation: Bartoletti M ( Department of Pharmacology, University of Bologna, Via Irnerio 48, I-40126 Bologna, Italy. maria.bartoletti@unibo.it) |
| Abstract | The GABA(B) agonists block the rewarding properties of opiates. However, the role of GABA(B) receptors in the discriminative properties of these drugs has received little attention. In this line, the present study was performed to investigate the effects of acute (Experiment 1) and chronic (Experiment 2) pretreatment with baclofen on the discriminative stimulus effects of morphine. Rats were trained to discriminate morphine (5mg/kgi.p.) from saline under a two-lever fixed-ratio schedule of food reinforcement. Experiment 1: a morphine generalization curve was obtained under standard conditions in control and baclofen (1 and 2mg/kgi.p.) pretreated animals. Acute baclofen pretreatment attenuated morphine-lever responding and response rate at both doses. Experiment 2: the animals were randomly divided in two groups and a morphine generalization curve was obtained in daily consecutive test sessions before (TEST1) and after (TEST2) chronic saline (Group I) or chronic baclofen (2mg/kg) (Group II) administration. As expected, chronic saline pretreatment was ineffective, while chronic baclofen pretreatment attenuated the stimulus properties of morphine, without modifying the rate-decreasing effect of the drug.The data support a role for GABAergic neurotransmission in the discriminative effects of opiates and demonstrate that a short-term treatment with baclofen is useful for decreasing the sensitivity to narcotic cue. |
| File Format | HTM / HTML |
| ISSN | 00913057 |
| Issue Number | 2 |
| Volume Number | 97 |
| e-ISSN | 18735177 |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-12-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Analgesics, Opioid Pharmacology Baclofen Discrimination (psychology) Drug Effects Gaba Agonists Morphine Animals Conditioning, Operant Discrimination Learning Dose-response Relationship, Drug Injections, Intraperitoneal Male Rats Rats, Sprague-dawley Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology |
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