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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mizuno, Makoto Kawamura, Hiroki Ishizuka, Yuta Sotoyama, Hidekazu Nawa, Hiroyuki |
| Description | Country affiliation: Japan Author Affiliation: Mizuno M ( Center for Transdisciplinary Research, Niigata University, Niigata, Japan. mizuno@bri.niigata-u.ac.jp) |
| Abstract | Abnormal signaling mediated by epidermal growth factor (EGF) or its receptor (ErbB) is implicated in the neuropathology of schizophrenia. Previously, we found that the anthraquinone derivative emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits ErbB1 signaling and ameliorates behavioral deficits of the schizophrenia animal model established by EGF challenge. In the present study, we assessed acute and subchronic effects of its administration on methamphetamine-triggered behavioral hyperactivation in rats. Prior subchronic administration of emodin (50mg/kg/day, 5days, p.o.) suppressed both higher acoustic startle responses and hyperlocomotion induced by acute methamphetamine challenge. In parallel, emodin also attenuated methamphetamine-induced increases in dopamine and its metabolites and decreases in serotonin and its metabolites. Emodin administered alone also had an effect on stereotypic movement but no influence on horizontal or vertical locomotor activity. In contrast to pre-treatment, post-treatment with emodin had no effect on behavioral sensitization to methamphetamine. Administration of emodin in parallel to or following repeated methamphetamine challenge failed to affect hyperlocomotion induced by methamphetamine re-challenges. These findings suggest that emodin has unique pharmacological activity, which interferes with acute methamphetamine signaling and behavior. |
| File Format | HTM / HTML |
| ISSN | 00913057 |
| Issue Number | 2 |
| Volume Number | 97 |
| e-ISSN | 18735177 |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-12-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Central Nervous System Stimulants Antagonists & Inhibitors Emodin Pharmacology Methamphetamine Motor Activity Drug Effects Reflex, Startle Animals Biogenic Monoamines Metabolism Blotting, Western Dopamine Dose-response Relationship, Drug Electrophoresis, Polyacrylamide Gel Mitogen-activated Protein Kinase 1 Mitogen-activated Protein Kinase 3 Rats Rats, Sprague-dawley Serotonin Signal Transduction Stereotyped Behavior Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology |
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