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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sahraei, Hedayat Etemadi, Leila Rostami, Parvin Pourmotabbed, Ali Zarrindast, Mohammad-Reza Shams, Jamal Ghoshooni, Hassan Noroozzadeh, Ali Esfandiari, Behnaz Salimi, Seyed Hossein |
| Description | Country affiliation: Iran Author Affiliation: Sahraei H ( Department of Physiology and Biophysics and Applied Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. h.sahraei@bmsu.ac.ir) |
| Abstract | The influence of intra-ventral tegmental area administration of gamma-amino-butyric-acid-B (GABAB) receptor agonist and antagonist on the expression and acquisition of morphine-induced conditioned place preference (CPP) in morphine-sensitized female rats was examined. Our pilot experiment showed that subcutaneous administration of morphine-(2.5, 5 and 7.5 mg/kg) induced CPP. Administration of one dose daily morphine (5 mg/kg) for 3 days followed by 5 days rest, enhanced the conditioning induced by ineffective doses of morphine (0.25, 0.5 and 1 mg/kg). Injections of GABAB receptor agonist, baclofen, (1.5 and 12 microg/rat) reduced the expression of morphine CPP whereas the dose of 6 microg/rat of the drug increased it. Baclofen also significantly reduced the acquisition of morphine CPP in morphine-sensitized animals. Administration of GABAB receptor antagonist, CGP 35348, significantly reduced the expression (12 microg/rat) and acquisition (1.5, 6 and 12 microg/rat) of morphine CPP in morphine-sensitized animals. In conclusion, results confirmed the importance of GABAB receptors within the ventral tegmental area of morphine CPP in morphine-sensitized female rats. |
| File Format | HTM / HTML |
| ISSN | 00913057 |
| Issue Number | 3 |
| Volume Number | 91 |
| e-ISSN | 18735177 |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Conditioning, Operant Drug Effects Morphine Pharmacology Narcotics Receptors, Gaba-a Physiology Ventral Tegmental Area Animals Baclofen Dose-response Relationship, Drug Female Gaba Agonists Gaba Antagonists Microinjections Administration & Dosage Motor Activity Organophosphorus Compounds Rats Rats, Wistar Receptors, Gaba-b Reinforcement (psychology) Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology |
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