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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Reyes-Cabello, Carmen Alen, Francisco Gómez, Raquel Serrano, Antonia Rivera, Patricia Orio, Laura Rodríguez de Fonseca, Fernando Pavón, Francisco Javier |
| Description | Country affiliation: Spain Author Affiliation: Reyes-Cabello C ( Laboratorio de Medicina Regenerativa, Hospital Regional Universitario Carlos Haya. Fundación IMABIS. Avenida Carlos Haya 82, sótano. Málaga 29010, Spain.) |
| Abstract | Endocannabinoids (anandamide and 2-AG) are relevant modulators of appetite and energy expenditure through their action on cannabinoid CB(1) receptors. The actions of anandamide on feeding behavior are dependent both, on the anatomical location of CB(1) receptors (central nervous system versus peripheral tissues) and the feeding status. Anandamide uptake into cells, prior to its degradation by specific enzymatic systems, is a necessary step for the regulation of its extracellular levels. The present study explores the route and feeding stimulus dependency of the effects of the anandamide uptake blocker AM404. Peripherally, AM404 reduced feeding in partially satiated animals through a PPAR -independent mechanism, but not in food deprived ones. When AM404 was injected into the cerebral ventricles of food deprived rats, it resulted in hyperphagia that was antagonized by the cannabinoid receptor inverse agonist SR141716A. These results support the multimodal action of endocannabinoid signaling in feeding regulation, which depends on the anatomical site and the feeding status of the animal. |
| File Format | HTM / HTML |
| ISSN | 00913057 |
| Issue Number | 1 |
| Volume Number | 101 |
| e-ISSN | 18735177 |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-03-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Arachidonic Acids Antagonists & Inhibitors Metabolism Pharmacology Eating Drug Effects Feeding Behavior Food Deprivation Physiology Polyunsaturated Alkamides Receptor, Cannabinoid, Cb1 Animals Administration & Dosage Endocannabinoids Energy Intake Injections, Intraperitoneal Injections, Intraventricular Male Mice Mice, Knockout Nutritional Status Oxazoles Ppar Alpha Genetics Piperidines Pyrazoles Rats Rats, Wistar Satiation Tyrosine Analogs & Derivatives Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology |
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