NDLI: CM156, a sigma receptor ligand, reverses cocaine-induced place conditioning and transcriptional responses in the brain.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Xu, Yan-Tong Robson, Matthew J. Szeszel-Fedorowicz, Wioletta Patel, Divyen Rooney, Robert McCurdy, Christopher R. Matsumoto, Rae R.
Description	Country affiliation: United States Author Affiliation: Xu YT ( Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA.)
Abstract	Repeated exposure to cocaine induces neuroadaptations which contribute to the rewarding properties of cocaine. Using cocaine-induced conditioned place preference (CPP) as an animal model of reward, earlier studies have shown that sigma (σ) receptor ligands can attenuate the acquisition, expression and reactivation of CPP. However, the underlying molecular mechanisms that are associated with these changes are not yet understood. In the present study, CM156, a novel antagonist with high selectivity and affinity for σ receptors was used to attenuate the expression of cocaine-induced CPP in mice. Immediately following the behavioral evaluations, mouse brain tissues were collected and alterations in gene expression in half brain samples were profiled by cDNA microarray analysis. Microarray data was analyzed by three distinct normalization methods and four genes were consistently found to be upregulated by cocaine when compared to saline controls. Each of these gene changes were found by more than one normalization method to be reversed by at least one dose of CM156. Quantitative real time PCR confirmed that a single administration of CM156 was able to reverse the cocaine-induced increases in three of these four genes: metastasis associated lung adenocarcinoma transcript 1 (malat1), tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein (ywhaz), and transthyretin (ttr). These genes are involved in processes related to neuroplasticity and RNA editing. The data presented herein provides evidence that pharmacological intervention with a putative σ receptor antagonist reverses alterations in gene expression that are associated with cocaine-induced reward.
File Format	HTM / HTML
ISSN	00913057
e-ISSN	18735177
DOI	10.1016/j.pbb.2011.12.016
Journal	Pharmacology Biochemistry and Behavior
Issue Number	1
Volume Number	101
Language	English
Publisher	Elsevier
Publisher Date	2012-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology 14-3-3 Proteins Genetics Brain Chemistry Drug Effects Cocaine Antagonists & Inhibitors Conditioning, Operant Gene Expression Piperazines Pharmacology Receptors, Sigma Sulfur Compounds Analysis Of Variance Animals Behavior, Animal Binding Sites Dna, Complementary Mice Mice, Inbred C57bl Microarray Analysis Motor Activity Prealbumin Biosynthesis Isolation & Purification Rna, Long Noncoding Rna, Untranslated Real-time Polymerase Chain Reaction Reinforcement Schedule Seizures Chemically Induced Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology

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CM156, a Sigma Receptor Ligand, Reverses Cocaine-Induced Place Conditioning and Transcriptional Responses in the Brain

A novel substituted piperazine, CM156, attenuates the stimulant and toxic effects of cocaine in mice.

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Sleep deprivation impairs the extinction of cocaine-induced environmental conditioning in mice.

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Differential effects of dopamine receptor subtype-specific agonists with respect to operant behavior maintained on a differential reinforcement of low-rate responding (DRL) schedule.

Intravenous cocaine self-administration: individual differences in male and female C57BL/6J mice.

CM156, a sigma receptor ligand, reverses cocaine-induced place conditioning and transcriptional responses in the brain.

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CM156, a Sigma Receptor Ligand, Reverses Cocaine-Induced Place Conditioning and Transcriptional Responses in the Brain

A novel substituted piperazine, CM156, attenuates the stimulant and toxic effects of cocaine in mice.

Demand for cocaine and food over time.

Hippocampal regulation of contextual cue-induced reinstatement of cocaine-seeking behavior.

Effects of N-phenylpropyl-N'-substituted piperazine sigma receptor ligands on cocaine-induced hyperactivity in mice.

Sleep deprivation impairs the extinction of cocaine-induced environmental conditioning in mice.

Lower reinforcing strength of the phenyltropane cocaine analogs RTI-336 and RTI-177 compared to cocaine in nonhuman primates.

Differential effects of dopamine receptor subtype-specific agonists with respect to operant behavior maintained on a differential reinforcement of low-rate responding (DRL) schedule.

Intravenous cocaine self-administration: individual differences in male and female C57BL/6J mice.

CM156, a sigma receptor ligand, reverses cocaine-induced place conditioning and transcriptional responses in the brain.