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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | da Veiga, Marco Aurélio Liberato Costa Fonseca Bloise, Flávia Costa-E-Sousa, Ricardo Henrique Souza, Luana Lopes Almeida, Norma Aparecida Dos Santos Oliveira, Karen Jesus Pazos-Moura, Carmen Cabanelas |
| Description | Country affiliation: Brazil Author Affiliation: da Veiga MA ( Laboratório de Endocrinologia Molecular, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21949-900, Brazil.) |
| Abstract | We examined the acute effects of endocannabinoid, anandamide, and of synthetic cannabinoid receptor antagonist, AM251[N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide], on TSH, thyroxine $(T_{4}),$ and triiodothyronine $(T_{3})$ secretions. Euthyroid male rats showed a 42% decrease in serum TSH, 2 h after a single i.p. injection of 0.02, but not 0.2 mg/kg body weight (BW), anandamide, accompanied by a 39% reduction in serum $T_{4},$ without alteration in serum $T_{3}.$ At 0.5 and 1 h, these serum hormones showed no significant change. Hypothyroid rats showed a 35% reduction in serum TSH (P<0.01), 2 h after anandamide injection, which had no effect on hyperthyroid rats. In both thyroid states, no modification of serum thyroid hormones was observed. Intraperitoneal injection of 0.17 or 1.7 mg/kg BW AM251 in euthyroid rats caused, 1.5 h later, 1.7-fold or 4.3-fold increase in serum TSH respectively, without changing thyroid hormones. Stimulatory effect of 0.17 mg/kg BW AM251 and inhibitory effect of anandamide was abolished in the group injected with AM251 followed by an anandamide injection, 30 min later. Intracerebroventricular injection of 20 ng (but not 200 ng) anandamide induced a decrease in serum TSH at 60 min after injection, which tended to disappear at 120 min. Anterior pituitary explants presented significant reduction in TSH release in the presence of $10^{−7} M$ anandamide in incubation medium, which was blocked by $10^{−7} M$ AM251. In conclusion, anandamide has the ability to acutely inhibit TSH release in eu- and hypothyroid rats, acting at the hypothalamus–pituitary axis. Since, in addition, the cannabinoid receptor antagonist AM251 increased TSH release, we suggest that endocannabinoid system has a role as negative regulator of TSH secretion. |
| File Format | HTM / HTML |
| ISSN | 00220795 |
| e-ISSN | 14796805 |
| Journal | Journal of Endocrinology |
| Issue Number | 2 |
| Volume Number | 199 |
| Language | English |
| Publisher | BioScientifica |
| Publisher Date | 2008-11-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Endocrinology Arachidonic Acids Pharmacology Cannabinoid Receptor Modulators Endocannabinoids Piperidines Polyunsaturated Alkamides Pyrazoles Receptor, Cannabinoid, Cb1 Antagonists & Inhibitors Thyrotropin Secretion Animals Administration & Dosage Hyperthyroidism Blood Drug Therapy Hypothyroidism In Vitro Techniques Pituitary Gland Drug Effects Metabolism Radioimmunoassay Rats, Wistar Thyroxine Triiodothyronine Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Endocrinology |
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