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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lopes, Ana Paula Fraga Ganzer, Laís Borges, Aline Caon Kochenborger, Larissa Januário, Ana Cláudia Faria, Moacir Serralvo Marino-Neto, José Paschoalini, Marta Aparecida |
| Description | Author Affiliation: Lopes AP ( Department of Physiological Sciences, Centre of Biological Sciences, Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil. anapfragalopes@gmail.com, marta@ccb.ufsc.br) |
| Abstract | In an attempt to establish a relationship between food intake and fear/anxiety-related behaviours, the goal of this study was to investigate the effect of bilateral injections of GABAA (Muscimol, MUS, doses 25 and 50ng/side) and GABAB (Baclofen, BAC, doses 32 and 64ng/side) receptor agonists in the nucleus accumbens shell (AcbSh) on the level of fear/anxiety-like and feeding behaviours in 24h food-deprived rats. The antagonists of GABAA (Bicuculline, BIC, doses 75 and 150ng/side) and GABAB (Saclofen, SAC, doses 1.5 and 3µg/side) were also tested. The results indicated that the total number of risk assessment behaviour decreased after the injection of both doses of GABAA agonist (MUS) into the AcbSh of 24h food-deprived rats exposed to elevated plus maze. Similar results were obtained after treatment with both doses of GABAB (BAC) agonist in the AcbSh. These data indicated that the activation of both GABAA and GABAB receptors within the AcbSh caused anxiolysis in 24h food-deprived rats. In addition, feeding behaviour (food intake, feeding latency and feeding duration) remained unchanged after treatment with both GABA agonists. In contrast, both food intake and feeding duration decreased after injections of both doses of BIC (GABAA antagonist), while the feeding latency remained unchanged after treatment with both GABA antagonists in the AcbSh of 24h food-deprived rats. The treatment with SAC (GABAB antagonist) did not affect feeding behaviour. Collectively, these data suggest that emotional changes evoked by pharmacological manipulation of the GABA neurotransmission in the AcbSh are not linked with changes in food intake. |
| File Format | HTM / HTML |
| ISSN | 00913057 |
| Issue Number | 1 |
| Volume Number | 101 |
| e-ISSN | 18735177 |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-03-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Anxiety Psychology Fear Feeding Behavior Drug Effects Food Deprivation Physiology Gaba Agents Pharmacology Nucleus Accumbens Animals Baclofen Analogs & Derivatives Behavior, Animal Bicuculline Eating Administration & Dosage Gaba Agonists Gaba Antagonists Gaba-a Receptor Agonists Gaba-a Receptor Antagonists Gaba-b Receptor Agonists Gaba-b Receptor Antagonists Male Microinjections Muscimol Anatomy & Histology Rats Rats, Wistar Stereotaxic Techniques Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology |
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