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Fatigue in survivors of childhood acute lymphoblastic and myeloid leukemia in Japan.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nagai, Ayako Zou, Ning Kubota, Masaru Kojima, Chiaki Adachi, Souichi Usami, Ikuya Okada, Masayuki Tanizawa, Akihiko Hamahata, Keigo Matsubara, Kousaku Higuchi, Manryoku Imaizumi, Masue
Spatial Coverage	Japan
Description	Country affiliation: Japan Author Affiliation: Nagai A ( Faculty of Human Life and Environment, Nara Women's University, Nara, Japan.)
Abstract	BACKGROUND: Fatigue in cancer survivors is a serious problem in pediatric oncology, but reports on this issue are limited, especially in Asian countries. METHODS: Sixty-three patients with acute lymphoblastic leukemia and 18 patients with acute myeloid leukemia who attended a follow-up outpatient clinic were enrolled. Participants were required to be >8 years of age, in remission, and without any cancer treatment for at least the previous 1 year. A control group consisted of 243 subjects whose age and gender were matched with the patient group. A questionnaire consisting of 12 items was devised for fatigue measurement. RESULTS: Principal factor analysis identified three dimensions, defined as physical fatigue, decreased function, and altered mood. The mean total and the three fatigue dimension scores tended to be higher in the control group, but significant differences between the scores were seen only in the total and physical fatigue scores. Multiple regression analysis indicated an association of present older age or shorter duration after completion of treatment with total and physical fatigue, and an association of presence of total body irradiation with decreased function. CONCLUSION: Pediatric leukemia survivors in Japan experience equal or less fatigue compared with that of controls in different fatigue dimensions. Elucidation of underlying mechanisms of cancer-related fatigue including the differences of cultural background among different countries is necessary for future study of this issue.
File Format	HTM / HTML
ISSN	13288067
Issue Number	2
Volume Number	54
e-ISSN	1442200X
Journal	Pediatrics International
Language	English
Publisher	Wiley
Publisher Date	2012-04-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pediatrics Leukemia, Myeloid, Acute Epidemiology Precursor Cell Lymphoblastic Leukemia-lymphoma Survivors Adolescent Adult Child Fatigue Female Humans Japan Male Principal Component Analysis Regression Analysis Questionnaires Young Adult Journal Article
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health

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