NDLI: Effect of body mass index-z score on adverse levels of cardiovascular disease risk factors.

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Effect of body mass index-z score on adverse levels of cardiovascular disease risk factors.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Katsuren, Keisuke Nakamura, Kimitoshi Ohta, Takao
Description	Country affiliation: Japan Author Affiliation: Katsuren K ( Department of Pediatrics, Faculty of Medicine, University of Ryukyus, Okinawa, Japan.)
Abstract	BACKGROUND: Cardiovascular disease (CVD) risk factors are associated with body mass index z-score (BMISD) and/or insulin resistance (IR). However, the correlation between adverse levels of these risk factors and BMISD, and the effect of IR on these associations are not fully understood in children. The aim of this study was to evaluate the association between adverse levels of CVD risk factors and BMISD, and the effect of IR on these associations in schoolchildren. METHODS: Conventional CVD risk factors, C-reactive protein (CRP), uric acid (UA) and adiponectin were determined in 757 boys and 494 girls aged between 7 and 12 years. IR was assessed by the homeostasis model approximation index. RESULTS: BMISD were linearly associated with relative risks having adverse levels of all factors, except for glucose and low-density lipoprotein cholesterol (LDL-C) in boys, and except for glucose, LDL-C and adiponectin in girls (P < 0.01-0.001). These associations were weakened after adjustment for IR, but still significant in cases of UA and CRP in boys and UA, high-density lipoprotein cholesterol and CRP in girls (P < 0.01-0.001). CONCLUSION: The relative risk of having adverse levels of most CVD risk factors in school children increased across the entire range of BMISD. IR contributed to most of these relative risks, but BMISD itself also contributed to these relative risks. To prevent future development of CVD, it might be important for schoolchildren to maintain BMISD within normal range. However, in cases of hyper LDL-cholesterolemia, we should consider causes other than BMISD.
File Format	HTM / HTML
ISSN	13288067
Issue Number	2
Volume Number	54
e-ISSN	1442200X
Journal	Pediatrics International
Language	English
Publisher	Wiley
Publisher Date	2012-04-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pediatrics Cardiovascular Diseases Epidemiology Physiopathology Insulin Resistance Physiology Adiponectin Blood Body Mass Index C-reactive Protein Analysis Child Female Humans Hypercholesterolemia Logistic Models Male Risk Factors Uric Acid Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health

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