NDLI: Tracheal aspirate gene expression in preterm newborns and development of bronchopulmonary dysplasia.

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Tracheal aspirate gene expression in preterm newborns and development of bronchopulmonary dysplasia.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hikino, Shunji Ohga, Shouichi Kinjo, Tadamune Kusuda, Takeshi Ochiai, Masayuki Inoue, Hirosuke Honjo, Satoshi Ihara, Kenji Ohshima, Koichi Hara, Toshiro
Description	Country affiliation: Japan Author Affiliation: Hikino S ( Departments of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.)
Abstract	BACKGROUND: Bronchopulmonary dysplasia (BPD) occurs in association with prenatal conditions predisposing infants to inflammation and remodeling of the premature lungs. Because of the lack of useful biomarkers for BPD, the gene expression of tracheal aspirate fluid (TAF) cells in premature infants was analyzed. METHODS: Of 148 consecutive patients, 26 preterm infants (gestational age <34 weeks) were enrolled, who underwent assisted ventilation at birth for respiratory failure. Patients with congenital disorders were excluded. Half of these infants developed BPD. Interleukin (IL)-10, interferon (IFN)-Î³, transforming growth factor (TGF)-ß1, and platelet-derived growth factor (PDGF)-B mRNA of TAF cells were quantified on real-time polymerase chain reaction. RESULTS: IL-10 (P < 0.01) and IFN-Î³ (P= 0.03) but not TGF-ß1 or PDGF-B mRNA levels at birth were higher in BPD than in non-BPD infants. IL-10 expression differentiated BPD with the highest sensitivity (92%) and specificity (77%). IL-10 levels correlated with TGF-ß1 (P= 0.03) and IFN-Î³ (P= 0.01), but not with PDGF-B levels. When BPD infants were classified according to comorbidity (group 1, six patients who suffered respiratory distress syndrome [RDS] but not chorioamnionitis [CAM]; group 2, five patients who had CAM but not RDS), PDGF-B levels were higher in group 2 (P= 0.01). High IL-10 expression was selected as a risk factor for BPD in infants who had CAM but not RDS (P= 0.01), although prolonged oxygen therapy was the most sensitive indicator for BPD (P < 0.01) on multivariate analysis. CONCLUSIONS: High IL-10 expression in TAF cells at birth could predict the evolution of BPD, but with less impact than oxygen requirement. PDGF might play a different role in the inflammatory process of premature lungs.
File Format	HTM / HTML
ISSN	13288067
Issue Number	2
Volume Number	54
e-ISSN	1442200X
Journal	Pediatrics International
Language	English
Publisher	Wiley
Publisher Date	2012-04-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pediatrics Bronchopulmonary Dysplasia Genetics Cytokines Gene Expression Infant, Premature Physiology Interleukin-10 Analysis Trachea Secretion Biological Markers Epidemiology Immunology Exudates And Transudates Female Humans Infant, Newborn Intercellular Signaling Peptides And Proteins Interferon-gamma Male Multivariate Analysis Neutrophils Prospective Studies Proto-oncogene Proteins C-sis Real-time Polymerase Chain Reaction Risk Factors Cytology Transforming Growth Factor Beta1 Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health

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