NDLI: Nanostructured chitosan-surfactant matrices as polyphenols nanocapsules template with zero order release kinetics.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gârlea, Ana Melnig, V. Popa, M. I.
Description	Country affiliation: Romania Author Affiliation: Gârlea A ( Department of Physics, Faculty of Physics, Alexandru Ioan Cuza din Iasi University, Iasi, Romania.)
Abstract	Nanostructured membranes and films of cationic surfactant-chitosan with tannic acid as polyphenol model were obtained by phase inversion method. The membranes were investigated by Attenuated Total Reflectance Fourier Transform InfraRred, X-Ray Diffraction, Scanning Electron Microscopy and Thermogravimetry, and the films topography was analysed by Atomic Force Microscopy. The analysis reveals that the interactions at the molecular level between cationic CTAB surfactant and cationic chitosan polymer strive to weaken membrane stability, whereas, the tannic acid is favoured to cluster with CTAB and diminish the membrane thermodynamic instability. The nanocapsules formed, with dimensions in the range of 16.35-27.68 nm, are congregating in clusters having dimensions in the domain of 50-300 nm. The layers resulted from these nanostructures arrangement constitute a surfactant-chitosan matrix with tannic acid suitable for drug controlled release with zero order kinetics.
File Format	HTM / HTML
ISSN	09574530
Issue Number	4
Volume Number	21
e-ISSN	15734838
Journal	Journal of Materials Science: Materials in Medicine
Language	English
Publisher	Springer
Publisher Date	2010-04-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Biomedical Engineering Chitosan Chemistry Drug Carriers Pharmacokinetics Flavonoids Nanocapsules Phenols Surface-active Agents Algorithms Delayed-action Preparations Kinetics Materials Testing Membranes, Artificial Microscopy, Atomic Force Models, Biological Nanostructures Polyphenols Spectroscopy, Fourier Transform Infrared X-ray Diffraction Evaluation Studies Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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