NDLI: Poor-responder patients do not benefit from intracytoplasmic morphologically selected sperm injection.

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Poor-responder patients do not benefit from intracytoplasmic morphologically selected sperm injection.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Setti, Amanda Souza Braga, Daniela Paes Almeida Ferreira Figueira, Rita Cassia Sávio Iaconelli, Assumpto Borges, Edson
Description	Country affiliation: Brazil Author Affiliation: Setti AS ( Fertility - Centro de Fertilização Assistida, Av. Brigadeiro Luis Antonio, 4545, Sao Paulo, SP, 01401-002, Brazil.)
Abstract	PURPOSE: To compare the outcomes of ICSI and IMSI in women presenting with poor ovarian response. METHODS: Data of IMSI cycles performed from January 2011 to December 2013 were included in this retrospective cohort study. Patients were divided into two groups: normoresponder patients (NR group; patients with > 4 oocytes retrieved) and poor-responder patients (PR group; patients with ≤ 4 oocytes retrieved). Patients who underwent IMSI were matched with patients who underwent ICSI in the same period. The ICSI and IMSI outcomes were compared in the NR and PR groups. RESULTS: A total of 414 matched cycles were included in this study. The NR group comprised 324 cycles (164 ICSI and 160 IMSI cycles), and the PR group comprised 90 cycles (43 ICSI and 47 IMSI cycles). In the NR group, no significant differences were observed between the ICSI- and IMSI-treated couples regarding cycle outcomes. In the PR group, fertilisation rate was significantly lower in IMSI-treated couples (53.9% ± 36.7% vs. 79.8% ± 29.3%). The proportion of cycles with embryo transfer (57.4 vs. 79.1%) and the number of transferred embryos (1.5 ± 0.8 vs. 1.9 ± 0.7) were significantly lower in IMSI compared with ICSI. Implantation, pregnancy and miscarriage rates were similar when ICSI or IMSI were performed. CONCLUSIONS: Our results suggest that unselected couples undergoing ICSI that present with poor ovarian response to controlled ovarian stimulation do not benefit from sperm selection under high magnification prior to ICSI.
File Format	HTM / HTML
ISSN	10580468
e-ISSN	15737330
DOI	10.1007/s10815-014-0422-x
Journal	Journal of Assisted Reproduction and Genetics
Issue Number	3
Volume Number	32
Language	English
Publisher	Springer
Publisher Date	2015-03-01
Publisher Place	Netherlands
Access Restriction	Open
Subject Keyword	Discipline Reproductive Medicine Discipline Genectics Fertilization Physiology Sperm Injections, Intracytoplasmic Spermatozoa Abortion, Spontaneous Embryo Transfer Infertility, Male Oocytes Pathology Pregnancy Pregnancy Rate
Content Type	Text
Resource Type	Article
Subject	Genetics Developmental Biology Reproductive Medicine Genetics (clinical) Obstetrics and Gynecology

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Intracytoplasmic sperm injection and conventional in vitro fertilization are complementary techniques in management of unexplained infertility.

Comparison of embryo quality between intracytoplasmic sperm injection and in vitro fertilization in sibling oocytes.

Efficacy of cryopreservation of embryos generated by intracytoplasmic sperm injection with spermatozoa from frozen testicular tissue.

The effects of sperm quality on embryo development after intracytoplasmic sperm injection.

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Frequency and patterns of premature sperm chromosome condensation in oocytes failing to fertilize after intracytoplasmic sperm injection.

Pregnancy with oocytes characterized by narrow perivitelline space and heterogeneous zona pellucida: is intracytoplasmic sperm injection necessary?

Comparison of day 2 embryo quality after conventional ICSI versus intracytoplasmic morphologically selected sperm injection (IMSI) using sibling oocytes.

Poor-responder patients do not benefit from intracytoplasmic morphologically selected sperm injection.

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Efficacy of cryopreservation of embryos generated by intracytoplasmic sperm injection with spermatozoa from frozen testicular tissue.

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Poor-responder patients do not benefit from intracytoplasmic morphologically selected sperm injection.