NDLI: Single nucleotide polymorphisms in the Anti-Müllerian hormone (AMH Ile(49)Ser) and Anti-Müllerian hormone type II receptor (AMHRII -482 A>G) as genetic markers in assisted reproduction technology.

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Single nucleotide polymorphisms in the Anti-Müllerian hormone (AMH Ile(49)Ser) and Anti-Müllerian hormone type II receptor (AMHRII -482 A>G) as genetic markers in assisted reproduction technology.

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Single nucleotide polymorphisms in the Anti-Müllerian hormone (AMH Ile(49)Ser) and Anti-Müllerian hormone type II receptor (AMHRII -482 A>G) as genetic markers in assisted reproduction technology.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Karagiorga, Iro Partsinevelos, George A. Mavrogianni, Despina Anagnostou, Elli Zervomanolakis, Ioannis Kallianidis, Konstantinos Drakakis, Petros Loutradis, Dimitris
Description	Author Affiliation: Karagiorga I ( Molecular Biology Unit, Division of Human Reproduction, 1st Department of Obstetrics and Gynaecology, Alexandra Hospital, Athens University Medical School, 80 Vasilissis Sofias Av, 11528, Athens, Greece, iro.karagiorga@yahoo.com.)
Abstract	PURPOSE: The aim of the study was to evaluate whether the presence Antimullerian hormone (AMH) and Antimullerian hormone type II receptor (AMHRII) single nucleotide polymorphisms (SNPs) Ile(49)Ser and -482A>G respectively are related to the assisted reproduction outcome. METHODS: A prospective cross-sectional observational study was conducted in order to assess the distribution of AMH and AMHRII SNPs in two cohorts, one of healthy women (N = 100) and the control group and the IVF/ICSI group (N = 151) consisted of women undergoing IVF/ICSI treatment for infertility. Furthermore, a prospective longitudinal observational study was performed on the latter group to assess possible associations of these SNPs with patients' characteristics and controlled ovarian stimulation (COS) and pregnancy outcome. RESULTS: Among non-carriers of the AMH (Ile(49)Ser) polymorphism, basal FSH levels were lower in those with more than two of previous IVF attempts and fertilization rate was statistically higher in those with peak serum E2 levels below 1500 pg/ml, whereas among non-carriers of the AMHRII (-482 A>G) polymorphism, number of follicles was higher in those with more than two previous IVF attempts and total dose of gonadotropins was lower in those with peak serum E2 levels above 1500 pg/ml. CONCLUSIONS: There was evidence that in specific subgroups of women undergoing IVF/ICSI, AMH and AMHRII SNPs may be related to patients' characteristics and controlled ovarian stimulation and pregnancy outcome and thus may provide a means for the prediction of ovarian response in specific subgroups of women entering an IVF/ICSI program.
File Format	HTM / HTML
ISSN	10580468
e-ISSN	15737330
DOI	10.1007/s10815-014-0403-0
Journal	Journal of Assisted Reproduction and Genetics
Issue Number	3
Volume Number	32
Language	English
Publisher	Springer
Publisher Date	2015-03-01
Publisher Place	Netherlands
Access Restriction	Open
Subject Keyword	Discipline Reproductive Medicine Discipline Genectics Anti-mullerian Hormone Genetics Genetic Markers Receptors, Peptide Receptors, Transforming Growth Factor Beta Reproductive Techniques, Assisted Fertilization In Vitro Ovulation Induction Polymorphism, Single Nucleotide Pregnancy Pregnancy Outcome Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Developmental Biology Reproductive Medicine Genetics (clinical) Obstetrics and Gynecology

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Single nucleotide polymorphisms in the Anti-Müllerian hormone (AMH Ile49Ser) and Anti-Müllerian hormone type II receptor (AMHRII −482 A>G) as genetic markers in assisted reproduction technology

Analyzing the possible involvement of anti-Müllerian hormone and anti-Müllerian hormone receptor II single nucleotide polymorphism in infertility.

Anti-Müllerian hormone (AMH): a reliable biomarker of oocyte quality in IVF.

Serum anti-Müllerian hormone predicts ovarian response and cycle outcome in IVF patients.

Clinical pregnancy in a woman with idiopathic hypogonadotropic hypogonadism and low AMH: utility of ovarian reserve markers in IHH.

Anti-mullerian hormone and cumulative pregnancy outcome in in-vitro fertilization.

Relationship Between Anti-Müllerian Hormone and In Vitro Fertilization-Embryo Transfer in Clinical Pregnancy

Obesity adversely affects serum anti-müllerian hormone (AMH) levels in Caucasian women.

Genome-wide association study meta-analysis identifies three novel loci for circulating anti-Müllerian hormone levels in women

Single nucleotide polymorphisms in the Anti-Müllerian hormone (AMH Ile(49)Ser) and Anti-Müllerian hormone type II receptor (AMHRII -482 A>G) as genetic markers in assisted reproduction technology.

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Single nucleotide polymorphisms in the Anti-Müllerian hormone (AMH Ile49Ser) and Anti-Müllerian hormone type II receptor (AMHRII −482 A>G) as genetic markers in assisted reproduction technology

Analyzing the possible involvement of anti-Müllerian hormone and anti-Müllerian hormone receptor II single nucleotide polymorphism in infertility.

Anti-Müllerian hormone (AMH): a reliable biomarker of oocyte quality in IVF.

Serum anti-Müllerian hormone predicts ovarian response and cycle outcome in IVF patients.

Clinical pregnancy in a woman with idiopathic hypogonadotropic hypogonadism and low AMH: utility of ovarian reserve markers in IHH.

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Single nucleotide polymorphisms in the Anti-Müllerian hormone (AMH Ile(49)Ser) and Anti-Müllerian hormone type II receptor (AMHRII -482 A>G) as genetic markers in assisted reproduction technology.