NDLI: Efficacy and safety of late-start Corifollitropin-alfa administration for controlled ovarian hyperstimulation in IVF: a cohort, case-control study.

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Efficacy and safety of late-start Corifollitropin-alfa administration for controlled ovarian hyperstimulation in IVF: a cohort, case-control study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Revelli, Alberto Pittatore, Giulia Casano, Simona Canosa, Stefano Evangelista, Francesca Benedetto, Chiara
Description	Author Affiliation: Revelli A ( Gynecology and Obstetrics I, Physiopathology of Reproduction and IVF Unit, S. Anna Hospital, Department of Surgical Sciences, University of Torino, Torino, Italy, AERRE99@YAHOO.COM.)
Abstract	OBJECTIVE: To investigate efficacy and safety of a controlled ovarian stimulation (COS) protocol in which a single dose of Corifollitropin-alfa (CF ) was administered on day 4 of a GnRH-antagonist cycle. DESIGN: Cohort case-control study. SETTING: University Hospital. PATIENTS: One hundred twenty-two normally cycling women expected to be normal responders to COS. INTERVENTIONS: In 61 patients, CF (100-150 µg) was injected subcutaneously on day 4 of a spontaneous menstrual cycle; a GnRH-antagonist was added from day 8 (fixed protocol; 0.25 mg/day). If needed to complete follicular maturation, recombinant FSH (rFSH) daily injections (150/200 IU/day) were given from day 11. A control group of 61 matched women was stimulated with daily subcutaneous injections of rFSH (100-150 U/day) from day 4 of the cycle, and received GnRH-antagonist (0.25 mg/day) from day 8. IVF or ICSI was performed according to the sperm characteristics, and 1-2 embryos were transferred in utero under US guidance on day 2. MAIN OUTCOME MEASURES: Number of retrieved cumulus-oocyte complexes (COCs), clinical pregnancy rate (PR), implantation rate (IR), ongoing PR at 10 weeks, number of injections/cycle, ovarian hyperstimulation syndrome (OHSS) rate. RESULTS: No cycle was cancelled and the mean number of retrieved COCs was comparable in patients and controls. About 60% of CF-alfa treated women had no need of daily rFSH addition, and the mean number of injections/cycle was significantly lower in the CF-alfa group than in controls (p < 0.05). The ongoing PR/transfer was 36.8% in CF-alfa group and 37.5% in controls. No patient developed severe OHSS, and the incidence of moderate OHSS was similar in cases and controls. CONCLUSIONS: CF may be started on day 4 of the cycle obtaining results comparable to those of a COS using day 4-start daily rFSH, with significantly less injections and a similar risk of OHSS.
File Format	HTM / HTML
ISSN	10580468
e-ISSN	15737330
DOI	10.1007/s10815-014-0426-6
Journal	Journal of Assisted Reproduction and Genetics
Issue Number	3
Volume Number	32
Language	English
Publisher	Springer
Publisher Date	2015-03-01
Publisher Place	Netherlands
Access Restriction	Open
Subject Keyword	Discipline Reproductive Medicine Discipline Genectics Fertilization In Vitro Drug Effects Follicle Stimulating Hormone, Human Administration & Dosage Infertility, Female Drug Therapy Ovulation Induction Case-control Studies Follicle Stimulating Hormone Pathology Oocyte Retrieval Pregnancy Pregnancy Rate Sperm Injections, Intracytoplasmic
Content Type	Text
Resource Type	Article
Subject	Genetics Developmental Biology Reproductive Medicine Genetics (clinical) Obstetrics and Gynecology

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