NDLI: Diuron exposure induces systemic and organ-specific toxicity following acute and sub-chronic exposure in male Wistar rats.

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Diuron exposure induces systemic and organ-specific toxicity following acute and sub-chronic exposure in male Wistar rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Domingues, Alexandre Barbisan, Luis Fernando Martins, Priscila Raquel Spinardi-Barbisan, Ana Lúcia Tozzi
Description	Country affiliation: Brazil Author Affiliation: Domingues A ( Department of Pathology, Botucatu Medical School, São Paulo State University - UNESP, Botucatu 18618-970, São Paulo, Brazil. domingues1@gmail.com)
Abstract	Diuron [3-(3,4-dichlorophenyl)-1,1-dimethylurea] is a substitute urea herbicide widely used on agricultural crops with potential mutagenic, teratogenic, reproductive and carcinogenic effects. Nonetheless, its toxic potential on the immune system needs a detailed assessment. Thus, in order to evaluate the adverse effect of this herbicide on lymphohematopoietic organs and macrophage activity, male Wistar rats were orally treated with Diuron at 125, 1250 and 2500 ppm for 14, 28 or 90 days. General signs of toxicity were observed in Diuron-treated groups (1250 and 2500 ppm), including reduced food intake and body weight gain, as well as higher relative weights for spleen, kidneys and liver (28 and 90-day toxicity studies) and elevated serum levels of ALT, albumin, total protein, creatinine and urea (28-day toxicity study). Diuron exposure caused a severe depletion of splenic white pulp compartments and cellularity, followed by a decreased number of CD4(+) T lymphocytes, increased extramedullary hematopoiesis and deposition of hemosiderin in red pulp. Despite alteration in macrophage spreading, the macrophagic activity was not significantly affected by the herbicide. Under these experimental conditions, the results suggest that Diuron exerts systemic and target-organ toxicity, mainly at higher concentration.
File Format	HTM / HTML
ISSN	13826689
Issue Number	3
Volume Number	31
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2011-05-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Diuron Toxicity Herbicides Animals Body Weight Drug Effects Bone Marrow Pathology Drinking Eating Hematopoietic System Hydrogen Peroxide Metabolism Immune System Liver Function Tests Lymphocyte Subsets Macrophages Male Nitric Oxide Organ Size Organ Specificity Oxidants Phagocytosis Rats Rats, Wistar Spleen Cytology Immunology Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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