NDLI: In Salvia miltiorrhiza, phenolic acids possess protective properties against amyloid ß-induced cytotoxicity, and tanshinones act as acetylcholinesterase inhibitors.

Please wait, while we are loading the content...

Study on the association between environmental cadmium exposure, cytochrome P450-mediated 20-HETE, heme-oxygenase-1 polymorphism and hypertension in Thai population residing in a malaria endemic areas with cadmium pollution.

Evaluation of radioprotective efficacy and possible mechanism of action of Aloe gel.

Development of nano alpha-ketoglutarate nebulization formulation and its pharmacokinetic and safety evaluation in healthy human volunteers for cyanide poisoning.

In Salvia miltiorrhiza, phenolic acids possess protective properties against amyloid ß-induced cytotoxicity, and tanshinones act as acetylcholinesterase inhibitors.

Role of carbon monoxide in impaired endothelial function mediated by acute second-hand tobacco, incense, and candle smoke exposures.

Ganoderma applanatum terpenes protect mouse liver against benzo( )pyren-induced oxidative stress and inflammation.

Cadmium-induced up-regulation of aldo-keto reductase 1C3 expression in human nasal septum carcinoma RPMI-2650 cells: Involvement of reactive oxygen species and phosphatidylinositol 3-kinase/Akt.

Effects of flour bleaching agent on mice liver antioxidant status and ATPases.

Toxicokinetics of naringin, a putative antitussive, after 184-day repeated oral administration in rats.

Histopathological changes in gill, liver and kidney of neotropical fish Colossoma macropomum exposed to paraquat at different temperatures.

The effect of aging and an ovariectomy operation on the level of phosphorylated CaM kinase II in the hippocampus of female mice prenatally exposed to diethylstilbestrol.

Year: 2011 Volume: 31 Issue: 2

Year: 2011 Volume: 31 Issue: 1

Year: 2010 Volume: 30

Year: 2010 Volume: 29

Year: 2009 Volume: 28

Year: 2009 Volume: 27

Year: 2008 Volume: 26

Year: 2008 Volume: 25

Year: 2007 Volume: 24

Year: 2007 Volume: 23

Year: 2006 Volume: 22

Year: 2006 Volume: 21

Year: 2005 Volume: 20

Year: 2005 Volume: 19

Year: 2004 Volume: 18

Year: 2004 Volume: 17

Year: 2004 Volume: 16

Year: 2004 Volume: 15

Year: 2003 Volume: 15

Year: 2003 Volume: 14

Year: 2003 Volume: 13

Year: 1996 Volume: 2

Year: 1996 Volume: 1

In Salvia miltiorrhiza, phenolic acids possess protective properties against amyloid ß-induced cytotoxicity, and tanshinones act as acetylcholinesterase inhibitors.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhou, Yongqiang Li, Weize Xu, Lei Chen, Lvyi
Description	Author Affiliation: Zhou Y ( New Medicine R&D Center, Disha Pharmaceutical Group, Weihai 264205, PR China. zhouyongqiangs1@163.com)
Abstract	Radix Salvia miltiorrhiza (RSM), a traditional Chinese medicinal herb, has been alleged to possess therapeutic effects against senile dementia, also known as Alzheimer's disease (AD). However, the effects of the major components in RSM on cytotoxicity induced by amyloid-ß peptide (Aß) and on acetylcholinesterase activity have not been studied in depth to date. In this report, the effects of RSM aqueous/ethanol extracts, total polyphenols, total tanshinones and 3 phenolic compounds against toxicity mediated by Aß(25-35) were tested with PC-12 cells. The results showed that Aß(25-35)-induced cytotoxicity was revised by RSM aqueous/ethanol extracts and total polyphenols and that danshensu and salvianolic acid B could protect PC-12 cells by blocking Aß(25-35)-induced Ca(2+)-intake, lactate dehydrogenase release, cell viability decrease and apoptosis. In addition, the activities of RSM extracts and relevant constituents in their inhibition of acetylcholinesterase were investigated using rat brain homogenates as an enzyme resource. Galanthamine hydrobromide, an accepted acetylcholinesterase inhibitor, was employed as a positive control agent. Our preliminary studies demonstrated that RSM ethanol extract, total tanshinones, tanshinone I and dihydrotanshinone I had remarkable inhibition effects on acetylcholinesterase in vitro. These findings suggest that both tanshinones and polyphenols in RSM are the active constituents responsible for the beneficial effects of this herb in AD treatment.
File Format	HTM / HTML
ISSN	13826689
Issue Number	3
Volume Number	31
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2011-05-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Amyloid Beta-peptides Antagonists & Inhibitors Cholinesterase Inhibitors Diterpenes, Abietane Pharmacology Hydroxybenzoates Neuroprotective Agents Salvia Miltiorrhiza Chemistry Toxicity Animals Antioxidants Apoptosis Drug Effects Benzofurans Calcium Metabolism Cell Survival L-lactate Dehydrogenase Male Pc12 Cells Phosphatidylinositols Plant Extracts Polyphenols Isolation & Purification Rats Rats, Sprague-dawley Tetrazolium Salts Thiazoles Journal Article
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The Biosynthetic Pathways of Tanshinones and Phenolic Acids in Salvia miltiorrhiza

Ag+ as a More Effective Elicitor for Production of Tanshinones than Phenolic Acids in Salvia miltiorrhiza Hairy Roots

Diterpenoid Tanshinones and Phenolic Acids from Cultured Hairy Roots of Salvia miltiorrhiza Bunge and Their Antimicrobial Activities

Overexpression of allene oxide cyclase promoted tanshinone/phenolic acid production in Salvia miltiorrhiza.

Tanshinones, Critical Pharmacological Components in Salvia miltiorrhiza

SmGRAS1 and SmGRAS2 Regulate the Biosynthesis of Tanshinones and Phenolic Acids in Salvia miltiorrhiza

Neuroprotective effects of pramipexole against tunicamycin-induced cell death in PC12 cells

Effects of tanshinones from Salvia miltiorrhiza on CYP2C19 activity in human liver microsomes: enzyme kinetic and molecular docking studies.

Overexpression of SmMYC2 Increases the Production of Phenolic Acids in Salvia miltiorrhiza

In Salvia miltiorrhiza, phenolic acids possess protective properties against amyloid ß-induced cytotoxicity, and tanshinones act as acetylcholinesterase inhibitors.

Similar Documents

The Biosynthetic Pathways of Tanshinones and Phenolic Acids in Salvia miltiorrhiza

Ag+ as a More Effective Elicitor for Production of Tanshinones than Phenolic Acids in Salvia miltiorrhiza Hairy Roots

Diterpenoid Tanshinones and Phenolic Acids from Cultured Hairy Roots of Salvia miltiorrhiza Bunge and Their Antimicrobial Activities

Overexpression of allene oxide cyclase promoted tanshinone/phenolic acid production in Salvia miltiorrhiza.

Tanshinones, Critical Pharmacological Components in Salvia miltiorrhiza

SmGRAS1 and SmGRAS2 Regulate the Biosynthesis of Tanshinones and Phenolic Acids in Salvia miltiorrhiza

Neuroprotective effects of pramipexole against tunicamycin-induced cell death in PC12 cells

Effects of tanshinones from Salvia miltiorrhiza on CYP2C19 activity in human liver microsomes: enzyme kinetic and molecular docking studies.

Overexpression of SmMYC2 Increases the Production of Phenolic Acids in Salvia miltiorrhiza

In Salvia miltiorrhiza, phenolic acids possess protective properties against amyloid ß-induced cytotoxicity, and tanshinones act as acetylcholinesterase inhibitors.