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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tonk, Elisa C. M. Verhoef, Aart de la Fonteyne, Liset J. J. Waalkens-Berendsen, Ine D. H. Wolterbeek, André P. M. Van Loveren, Henk Piersma, Aldert H. |
| Description | Country affiliation: Netherlands Author Affiliation: Tonk EC ( Department of Toxicogenomics, Maastricht University, Maastricht, The Netherlands. ilse.tonk@rivm.nl) |
| Abstract | To determine relevant endpoints for evaluating developmental immunotoxicity due to juvenile exposure and optimal age of the animals at assessment, a wide range of immunological parameters were assessed in a juvenile toxicity study. Rats were exposed to di-n-octyltin dichloride (DOTC) by gavage from postnatal day (PND) 10 through PND 21 and via the diet after weaning using a benchmark dose (BMD) approach. Immune assessments were performed in male rats on PNDs 21, 42, and 70 and a subset of animals was used to evaluate the T-cell dependent antibody response (TDAR) to Keyhole limpet hemocyanin. Immune effects were more pronounced on PND 21 and 42 and observed at lower doses than developmental effects. The most sensitive immune parameters affected included TDAR parameters and thymocyte subpopulations with lower confidence limits of the benchmark doses (BMDLs) below the overall no-observed-adverse-effect-level (NOAEL) for DOTC reported so far in literature. These findings illustrate the relative sensitivity of the developing immune system for DOTC, the additional value of assessing functional immune parameters, and underscore the relevance of juvenile immunotoxicity testing in view of the risk assessment of chemicals. |
| File Format | HTM / HTML |
| ISSN | 08906238 |
| Issue Number | 3 |
| Volume Number | 32 |
| e-ISSN | 18731708 |
| Journal | Reproductive Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-11-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Embryology Discipline Reproductive Medicine Discipline Toxicology Environmental Pollutants Toxicity Organotin Compounds T-lymphocyte Subsets Drug Effects Age Factors Animals Brain Growth & Development Cytokines Immunology Erythrocyte Indices Female Hematocrit Hemocyanin Immunoglobulin G Kidney Leukocyte Count Liver Male Nitric Oxide Metabolism Organ Size Rats Rats, Wistar Spleen Thymus Gland Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Toxicology |
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