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Evaluation of four Cameroonian medicinal plants for anticancer, antigonorrheal and antireverse transcriptase activities.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mbaveng, Armelle T. Kuete, Victor Mapunya, Brenda M. Beng, Veronique P. Nkengfack, Augustin E. Meyer, Jacobus J. Marion Lall, Namrita
Spatial Coverage	Cameroon
Description	Country affiliation: Cameroon Author Affiliation: Mbaveng AT ( Department of Biochemistry, Faculty of Science, University of Yaoundé I, Cameroon. armkuete@yahoo.fr)
Abstract	Methanol extracts from the leaves, bark and roots of four Cameroonian medicinal plants, Bersama engleriana, Cupressus lusitanica, Vitellaria paradoxa and Guibourtia tessmannii were tested for their in vitro cytotoxicity, antigonorrheal and antireverse transcriptase activities. The XTT (2,3-bis[2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-carboxyanilide inner salt) assay, the dilution method and reverse transcriptase (RT) assay were used for the investigations. Preliminary phytochemical analysis of the extracts was also conducted using standard methods. Results showed that all extracts contained compounds belonging to the classes of phenols and terpenoids. They were also able to reduce in dose dependent manner, the proliferation of the cancer THP-1, DU145, HeLa, MCF-7, HepG2 and the normal Vero cells. IC(50) values below 30µg/ml were noted with extract from the three parts of B. engleriana on at least two of the five studied cancer cell lines, the lowest value of 5.9µg/ml being obtained with sample from the bark. IC(50) values below 30µg/ml were also recorded with extracts from the leaves (on HeLa cells) and bark (on MCF-7) of G. tessmanii, and that from the bark of C. lusitanica on MCF-7. Extracts from B. engleriana and those from the bark of V. paradoxa gave the minimal inhibitory concentrations (MIC) values below 100µg/ml on most of the 10 tested Nesseria gonorrhoeae strains. Extracts from B. engleriana also inhibited more than 80% the activity of the Human Immuno-deficiency Virus (HIV) enzyme. Finally, the results of the present study provide baseline information for the use of B. engleriana, C. lusitanica, G. tessmanii, V. paradoxa.
File Format	HTM / HTML
ISSN	13826689
Issue Number	2
Volume Number	32
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2011-09-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Anti-bacterial Agents Pharmacology Antineoplastic Agents Hiv Reverse Transcriptase Antagonists & Inhibitors Neisseria Gonorrhoeae Drug Effects Plant Extracts Plants, Medicinal Chemistry Reverse Transcriptase Inhibitors Animals Therapeutic Use Cameroon Cell Line, Tumor Cercopithecus Aethiops Gonorrhea Drug Therapy Humans Microbial Sensitivity Tests Neoplasms Phenols Anatomy & Histology Terpenes Vero Cells Evaluation Studies Journal Article
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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