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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gul, Husamettin Uysal, Bulent Cakir, Erdinc Yaman, Halil Macit, Enis Yildirim, Ali Osman Eyi, Yusuf Emrah Kaldirim, Umit Oztas, Emin Akgul, Emin Ozgur Cayci, Tuncer Ozler, Mehmet Topal, Turgut Oter, Sukru Korkmaz, Ahmet Toygar, Mehmet Demirbag, Suzi |
| Description | Country affiliation: Turkey Author Affiliation: Gul H ( Department of Toxicology, Gulhane Military Medical Academy, Etlik, Ankara, Turkey. hgul23@gmail.com) |
| Abstract | OBJECTIVES: Acetaminophen (APAP) overdose may cause acute liver injury. Ozone therapy (OT) is shown to reduce inflammation and necrosis in several entities. Thus, we have designed this study to evaluate the efficacy of OT in a rat model of APAP-induced liver injury. METHODS: Twenty-seven Sprague-Dawley rats were divided into three groups: sham, APAP and APAP+OT groups. In the APAP and the APAP+OT groups, liver injury was induced by oral administration of 1 g/kg APAP. The APAP+OT group received a single dose ozone/oxygen mixture (0.7 mg/kg) intraperitoneally 1h after APAP administration. All animals were killed at 24 hour after APAP administration. Blood samples and liver tissues were harvested to determine liver injury and oxidative stress parameters. Liver tissues and blood samples were obtained for biochemical and histopathological analyses. RESULTS: APAP administration caused necrosis in the liver after 24h. The degrees of liver necrosis of the APAP group were higher than the other groups (in both p<0.05, respectively). In the APAP+OT group, liver antioxidant enzymes activities were significantly higher than the APAP group (p<0.05), but were lower than the sham group (p<0.05). In the sham group, serum neopterin, a marker of cell-mediated immunity, concentrations (4.8±1.2 nmol/L) were lower than the APAP (14.7±1.4 nmol/L) and APAP+OT groups (7.5±2.4 nmol/L) (in both p<0.05, respectively). CONCLUSION: Our results showed that OT prevented liver necrosis in rats and reduced neopterin levels. These findings suggest that the use of OT as an adjuvant therapy which might improve the outcome in APAP induced liver injury. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 1 |
| Volume Number | 34 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-07-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Acetaminophen Toxicity Analgesics, Non-narcotic Drug-induced Liver Injury Drug Therapy Ozone Therapeutic Use Protective Agents Alanine Transaminase Metabolism Animals Aspartate Aminotransferases Pathology Disease Models, Animal Glutathione Peroxidase Liver Drug Effects Male Malondialdehyde Necrosis Chemically Induced Neopterin Blood Nitrates Nitrites Rats Rats, Sprague-dawley Superoxide Dismutase Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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