NDLI: The toxicity potential of pharmaceuticals found in the Douro River estuary (Portugal): evaluation of impacts on fish liver, by histopathology, stereology, vitellogenin and CYP1A immunohistochemistry, after sub-acute exposures of the zebrafish model.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Madureira, Tânia Vieira Rocha, Maria João Cruzeiro, Catarina Rodrigues, Iolanda Monteiro, Rogério A. F. Rocha, Eduardo
Spatial Coverage	Portugal
Description	Country affiliation: Portugal Author Affiliation: Madureira TV ( Superior Institute of Health Sciences-North (ISCS-N), CESPU, Gandra, Paredes, Portugal.)
Abstract	Qualitative and quantitative approaches were tested to assess zebrafish liver effects after sub-acute exposures of certain pharmaceuticals. Carbamazepine, fenofibric acid, propranolol, sulfamethoxazole and trimethoprim were tested individually and in mixtures, including low environmental levels. Overall, data showed sex specific reactions in liver, with the major alterations being observed in males. Males treated with propranolol, fenofibric acid and with mixtures, showed an increase of vitellogenin immunostaining, compared with the control. Males also evidenced a tendency for an increased hepatic mass, after individual and mixture exposures. The volume-weighted nuclear volume of hepatocytes was high in males after exposures to either mixture, which together with the greater cytoplasmic eosinophilia and changes in cytochrome P450 1A immunoreactivity, point to an increase in metabolic/detoxification activity. These investigations revealed distinct impacts depending on the exposure type, and strengthened the importance of studying non-steroidal compounds in mixtures, including environmental levels and both sexes.
File Format	HTM / HTML
ISSN	13826689
Issue Number	1
Volume Number	34
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2012-07-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Liver Drug Effects Water Pollutants, Chemical Toxicity Animals Carbamazepine Cytochrome P-450 Cyp1a1 Metabolism Female Fenofibrate Analogs & Derivatives Fish Proteins Pathology Male Portugal Propranolol Rivers Sulfamethoxazole Trimethoprim Vitellogenins Zebrafish Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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The toxicity potential of pharmaceuticals found in the Douro River estuary (Portugal)--experimental assessment using a zebrafish embryo test.

Spatiotemporal distribution of pharmaceuticals in the Douro River estuary (Portugal).

The toxicity potential of pharmaceuticals found in the Douro River estuary (Portugal): assessing impacts on gonadal maturation with a histopathological and stereological study of zebrafish ovary and testis after sub-acute exposures.

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The toxicity potential of pharmaceuticals found in the Douro River estuary (Portugal): evaluation of impacts on fish liver, by histopathology, stereology, vitellogenin and CYP1A immunohistochemistry, after sub-acute exposures of the zebrafish model.

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Testing the effects of ethinylestradiol and of an environmentally relevant mixture of xenoestrogens as found in the Douro River (Portugal) on the maturation of fish gonads--a stereological study using the zebrafish (Danio rerio) as model.

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