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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shen, Baode Chen, Hongge Shen, Chengying Xu, Pinghua Li, Juanjuan Shen, Gang Yuan, Hailong Han, Jin |
| Description | Author Affiliation: Shen B ( Department of Pharmacy, 302 Hospital of PLA, Beijing 100039, PR China.); Chen H ( Department of Pharmacy, 302 Hospital of PLA, Beijing 100039, PR China.); Shen C ( Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611139, PR China.); Xu P ( Department of Pharmacy, 302 Hospital of PLA, Beijing 100039, PR China.); Li J ( Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611139, PR China.); Shen G ( Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611139, PR China.); Yuan H ( Department of Pharmacy, 302 Hospital of PLA, Beijing 100039, PR China. Electronic address: yhlpharm@126.com.); Han J ( Department of Pharmacy, 302 Hospital of PLA, Beijing 100039, PR China. Electronic address: hanjin302emba@126.com.) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Herpetospermum caudigerum (HCD) is traditionally used for the treatment of liver diseases, cholic diseases, and dyspepsia as a well-known Tibetan medicine in China. The present study was designed to investigate the hepatoprotective effect of HCD and ascertain its active ingredients and possible mechanism. MATERIALS AND METHODS: Mice were orally administrated with different parts (seeds, testa and kernel) and fractions of HCD. The hepatoprotective activities of different parts (seeds, testa and kernel) and three fractions (petroleum ether fraction, ethyl acetate fraction and aqueous fraction) with different polarities of HCD and herpetrione (HPE) isolated from HCD were determined using a mouse model of CCl4-induced liver injury based on the analysis of serum ALT and AST activities and the changes of antioxidant parameters like malondialdehyde (MDA) content, glutathione (GSH) level, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in the liver. Moreover, the chemical analysis of different parts and fractions of HCD was later analyzed by HPLC. RESULTS: Our results showed that the ethyl acetate fraction and HPE significantly alleviated liver injury as indicated by the decreased levels of serum ALT and AST and reduce the pathological tissue damage induced by CCl4. Moreover, they decreased the MDA content and increased the levels of SOD, GSH and GSH-Px. Chemical analysis indicated that the ethyl acetate fraction were rich in HPE. CONCLUSIONS: The lignans extract of Herpetospermum caudigerum is effective for the prevention of CCl4-induced hepatic damage in mice and HPE may be partially responsible for the pharmacological effect of hepatoprotection. The hepatoprotective effect may be related to its free radical scavenging effect, inhibiting lipid peroxidation and increasing antioxidant activity. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Volume Number | 164 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-04-22 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Drug-induced Liver Injury Drug Therapy Cucurbitaceae Furans Therapeutic Use Lignans Plant Extracts Protective Agents Alanine Transaminase Blood Animals Aspartate Aminotransferases Carbon Tetrachloride Metabolism Pathology Pharmacology Glutathione Glutathione Peroxidase Liver Drug Effects Malondialdehyde Mice Phytotherapy Seeds Superoxide Dismutase Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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