NDLI: Genetic polymorphisms of the CYP3A4, CYP3A5, CYP3A7 and CYP1A2 among the Jordanian population.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Salameh, Ghada Al Hadidi, Kamal El Khateeb, Mohammad
Spatial Coverage	Jordan
Description	Country affiliation: Jordan Author Affiliation: Salameh G ( Pathology, Microbiology and Forensic Department, University of Jordan, Amman, Jordan. gsalameh79@gmail.com)
Abstract	Cytochromes P450 (CYP450) plays an extremely vital role in oxidation, reduction, and peroxidation of numerous endogenous and exogenous compounds, like drugs and procarcinogens. Mainly, expression occurs in the liver, in varying polymorphic forms. Therefore, proposed as biomarkers of susceptibility to carcinogenicity and toxicity. The objective of this study was to find the allelic frequencies of CYP3A52,3,4,5,6,7, CYP3A41B, CYP3A71C and CYP1A21C, 1D, 1E, 1F enzymes in Jordanians, and to compare them with other ethnic groups. We used polymerase chain reaction-restriction fragment length (PCR-RFLP) to genotype alleles, and we calculated frequencies using Hardy Weinberg's equation (HWE). Allelic frequencies results were: CYP3A52 (0.2%), CYP3A53 (86.6%), CYP3A56 (1.7%), CYP3A54,57 not detected, CYP3A41B (11.7%), CYP3A71C (1.7%). Finally 6.5%, 18.2%, 6.0%, 67.3% were the results of CYP1A21C, 1D, 1E and 1F, respectively. In conclusion, genotyping method and results of this study can be adopted or used in pharmacotherapy, toxicity and carcinogenic studies in Jordan.
File Format	HTM / HTML
ISSN	13826689
Issue Number	1
Volume Number	34
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2012-07-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Cytochrome P-450 Cyp1a2 Genetics Cytochrome P-450 Cyp3a Gene Frequency Genotype Humans Jordan Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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