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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jamialahmadi, Khadijeh Arasteh, Omid Matbou Riahi, Maryam Mehri, Soghra Riahi-Zanjani, Bamdad Karimi, Gholamreza |
| Description | Country affiliation: Iran Author Affiliation: Jamialahmadi K ( Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran); Arasteh O ( School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.); Matbou Riahi M ( Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.); Mehri S ( Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.); Riahi-Zanjani B ( Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.); Karimi G ( Medical Toxicology Research Center and Pharmacy School, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: Karimig@mums.ac.ir.) |
| Abstract | Glucosamine (GlcN) is an important precursor in the biochemical synthesis of glycosylated proteins and lipids in human body. It gains importance because of its contribution to human health and its multiple biological and therapeutic effects. In this study, the in vitro oxidative hemolysis of rat erythrocyte was used as a model to study the potential protective effect of glucosamine hydrochloride against free radical-induced damage of biological membranes. Glucosamine hydrochloride exhibited dose-dependent DPPH antioxidant activity. Oxidative hemolysis and lipid/protein peroxidation of erythrocytes induced by a water-soluble free radical initiator 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) were significantly suppressed by GlcN in a time and dose dependent manner. GlcN also prevented the depletion of cytosolic antioxidant glutathione (GSH) in erythrocytes. These results indicated that glucosamine hydrochloride efficiently protected erythrocytes against free radicals and it could be recommended as a pharmaceutical supplement to alleviate oxidative stress. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 1 |
| Volume Number | 38 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-07-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Antioxidants Pharmacology Erythrocytes Drug Effects Glucosamine Animals Metabolism Free Radicals Glutathione Hemolysis Lipid Peroxidation Male Protein Carbonylation Rats, Wistar Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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