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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mustapha, Oluwaseun Oke, Bankole Offen, Nils Sirén, Anna-Leena Olopade, James |
| Description | Author Affiliation: Mustapha O ( Department of Veterinary Anatomy, University of Ibadan, Nigeria); Oke B ( Department of Veterinary Anatomy, University of Ibadan, Nigeria. Electronic address: bankoleoke@yahoo.com.); Offen N ( Department of Neurosurgery, University of Würzburg, Josef-Schneider Strasse 11, 97080 Würzburg, Germany. Electronic address: nils.offen@med.lu.se.); Sirén AL ( Department of Neurosurgery, University of Würzburg, Josef-Schneider Strasse 11, 97080 Würzburg, Germany. Electronic address: siren.a@ukw.de.); Olopade J ( Department of Veterinary Anatomy, University of Ibadan, Nigeria) |
| Abstract | Vanadium exposure has been known to lead to lipid peroxidation, demyelination and oligodendrocytes depletion. We investigated behaviour and glial reactions in juvenile mice after early neonatal exposure to vanadium, and examined the direct effects of vanadium in oligodendrocyte progenitor cultures from embryonic mice. Neonatal pups exposed to vanadium via lactation for 15 and 22 days all had lower body weights. Behavioural tests showed in most instances a reduction in locomotor activity and negative geotaxis. Brain analyses revealed astrocytic activation and demyelination in the vanadium exposed groups compared to the controls. In cell culture, exposure of oligodendrocytes to 300 µM sodium metavanadate significantly increased cell death. Expression of the oligodendrocyte specific proteins, 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) and oligodendrocyte specific protein (OSP/Claudin) were reduced upon vanadium treatment while simultaneous administration of erythropoietin (EPO; 4-12 U/ml) counteracted vanadium-toxicity. The data suggest that oligodendrocyte damage may explain the increased vulnerability of the juvenile brain to vanadium and support a potential for erythropoietin as a protective agent against vanadium-toxicity during perinatal brain development and maturation. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 1 |
| Volume Number | 38 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-07-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Antimitotic Agents Toxicity Erythropoietin Pharmacology Neuroprotective Agents Neurotoxins Oligodendroglia Drug Effects Vanadium 2',3'-cyclic-nucleotide Phosphodiesterases Metabolism Animals Anxiety Drug Therapy Behavior, Animal Brain Cell Differentiation Cell Survival Cells, Cultured Claudins Exploratory Behavior Female Glial Fibrillary Acidic Protein Mice Mice, Inbred C57bl Motor Activity Nerve Tissue Proteins Cytology Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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