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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Khazaeli, Payam Sharifi, Iraj Talebian, Elham Heravi, Gioia Moazeni, Esmaeil Mostafavi, Mahshid |
| Description | Country affiliation: Iran Author Affiliation: Khazaeli P ( Pharmaceutical Research Center, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.); Sharifi I ( Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran. Electronic address: iraj.sharifi@yahoo.com.); Talebian E ( Pharmaceutical Research Center, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.); Heravi G ( Pharmaceutical Research Center, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.); Moazeni E ( Pharmaceutical Research Center, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.); Mostafavi M ( Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran.) |
| Abstract | The novel niosomal system aimed to deliver the active drug entity to the target site. The objective of this study was to prepare and evaluate the effect of itraconazole niosome on the in vitro susceptibility of Leishmania tropica as compared to itraconazole alone or tartar emetic. The overall growth rate of promastigotes treated with various concentrations of itraconazole niosome was significantly lower than that of itraconazole alone (IC50=0.24 µg/ml vs. IC50=0.43 µg/ml, P<0.01). In contrast, the mean multiplication rate of amastigotes inside the macrophages and also the mean number of amastigotes in each macrophage treated with itraconazole niosome (34.9 and 3.0) were significantly lower (P<0.01) than those treated with itraconazole alone (62.0 and 3.8) or tartar emetic (63.9 and 4.2), respectively. These findings indicated that niosomes could be developed as a novel drug delivery for itraconazole in the in vitro model. Further studies are required to evaluate the effect of itraconazole niosome on volunteer human subjects. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 1 |
| Volume Number | 38 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-07-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Antiprotozoal Agents Administration & Dosage Itraconazole Leishmania Tropica Drug Effects Animals Cholesterol Chemistry Drug Liberation Hexoses Growth & Development Liposomes Macrophages, Peritoneal Microbiology Mice, Inbred Balb C Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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