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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rocha, Thiago Lopes Santos, Ana Paula Rezende Dos Yamada, Áureo Tatsumi Soares, Célia Maria de Almeida Borges, Clayton Luiz Bailão, Alexandre Melo Sabóia-Morais, Simone Maria Teixeira |
| Description | Country affiliation: Brazil Author Affiliation: Rocha TL ( Laboratório de Comportamento Celular, Departamento de Morfologia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.); Santos AP ( Laboratório de Comportamento Celular, Departamento de Morfologia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.); Yamada ÁT ( Laboratório de Citoquímica e Imunocitoquímica, Departamento de Histologia e Embriologia, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.); Soares CM ( Laboratório de Biologia Molecular, Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.); Borges CL ( Laboratório de Biologia Molecular, Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.); Bailão AM ( Laboratório de Biologia Molecular, Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.); Sabóia-Morais SM ( Laboratório de Comportamento Celular, Departamento de Morfologia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil. Electronic address: simonesaboias@gmail.com.) |
| Abstract | Glyphosate-based herbicides (GBH) are one of the most used herbicide nowadays, whilst there is growing concern over their impact on aquatic environment. Since data about the early proteomic response and toxic mechanisms of GBH in fish is very limited, the aim of this study was to investigate the early toxicity of GBH in the gills of guppies Poecilia reticulata using a proteomic approach associated with histopathological index. Median lethal concentration (LC50,96 h) was determined and LC50,96h values of guppies exposed to GBH were 3.6 ± 0.4 mg GLIL(-1). Using two-dimensional gel electrophoresis associated with mass spectrometry, 14 proteins regulated by GBH were identified, which are involved in different cell processes, as energy metabolism, regulation and maintenance of cytoskeleton, nucleic acid metabolism and stress response. Guppies exposed to GBH at 1.82 mg GLIL(-1) showed time-dependent histopathological response in different epithelial and muscle cell types. The histopathological indexes indicate that GBH cause regressive, vascular and progressive disorders in the gills of guppies. This study helped to unravel the molecular and tissue mechanisms associated with GBH toxicity, which are potential biomarkers for biomonitoring water pollution by herbicides. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 1 |
| Volume Number | 40 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-07-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Gills Drug Effects Glycine Analogs & Derivatives Herbicides Toxicity Poecilia Metabolism Physiology Proteomics Animals Pathology Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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