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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Martín-Cameán, Ana Jos, Ángeles Mellado-García, Pilar Iglesias-Linares, Alejandro Solano, Enrique Cameán, Ana M. |
| Description | Author Affiliation: Martín-Cameán A ( Stomatology Department, School of Dentistry, University of Sevilla, Spain. Electronic address: amartincamean@gmail.com.); Jos Á ( Area of Toxicology, Faculty of Pharmacy, University of Sevilla, Spain.); Mellado-García P ( Area of Toxicology, Faculty of Pharmacy, University of Sevilla, Spain.); Iglesias-Linares A ( Stomatology Department, School of Dentistry, University Complutense of Madrid, Spain.); Solano E ( Stomatology Department, School of Dentistry, University of Sevilla, Spain.); Cameán AM ( Area of Toxicology, Faculty of Pharmacy, University of Sevilla, Spain.) |
| Abstract | Intraoral fixed orthodontic appliances are frequently used in the clinical practice of dentistry. They are made from alloys containing different metals at various percentages. The use of these appliances leads to the long-term exposure of patients to these materials, and the potential toxic effects of this exposure raises concerns about patient safety. Thus, the biocompatibility (corrosion behaviour and toxicity) of these materials has to be evaluated prior to clinical use. In the present report, the most recent studies in the scientific literature examining metal ion release from orthodontic appliances and the toxic effects of these ions have been reviewed with a special focus on cytotoxicity and genotoxicity. Previous studies suggest that a case-by-case safety evaluation is required to take into account the increasing variability of materials, their composition and the manufacturing processes. Moreover, in vivo toxicity studies in regard to metal release, cytotoxicity and genotoxicity are still scarce. Therefore, in vitro and in vivo monitoring studies are needed to establish cause-effect relationships between metal ion release and biomarkers of cytotoxicity and genotoxicity. Further investigations could be performed to elucidate the toxic mechanisms involved in the observed effects with a special emphasis on oxidative damage. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 1 |
| Volume Number | 40 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-07-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Carcinogens Toxicity Metals Mutagens Orthodontic Appliances Humans In Vitro Techniques Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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