NDLI: Effect of olfactory manganese exposure on anxiety-related behavior in a mouse model of iron overload hemochromatosis

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ye, Qi Kim, Jonghan
Description	Country affiliation: United States Author Affiliation: Ye Q ( Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.); Kim J ( Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA. Electronic address: j.kim@neu.edu.)
Abstract	Manganese in excess promotes unstable emotional behavior. Our previous study showed that olfactory manganese uptake into the brain is altered in Hfe(-/-) mice, a model of iron overload hemochromatosis, suggesting that Hfe deficiency could modify the neurotoxicity of airborne manganese. We determined anxiety-related behavior and monoaminergic protein expression after repeated intranasal instillation of MnCl2 to Hfe(-/-) mice. Compared with manganese-instilled wild-type mice, Hfe(-/-) mice showed decreased manganese accumulation in the cerebellum. Hfe(-/-) mice also exhibited increased anxiety with decreased exploratory activity and elevated dopamine D1 receptor and norepinephrine transporter in the striatum. Moreover, Hfe deficiency attenuated manganese-associated impulsivity and modified the effect of manganese on the expression of tyrosine hydroxylase, vesicular monoamine transporter and serotonin transporter. Together, our data indicate that loss of HFE function alters manganese-associated emotional behavior and further suggest that HFE could be a potential molecular target to alleviate affective disorders induced by manganese inhalation.
File Format	HTM / HTML
ISSN	13826689
e-ISSN	18727077
DOI	10.1016/j.etap.2015.06.016
Journal	Environmental Toxicology and Pharmacology
Issue Number	1
Volume Number	40
Language	English
Publisher	Elsevier
Publisher Date	2015-07-01
Publisher Place	Netherlands
Access Restriction	Open
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Anxiety Chemically Induced Hemochromatosis Psychology Manganese Toxicity Administration, Intranasal Animals Biogenic Monoamines Metabolism Corpus Striatum Disease Models, Animal Dopamine Histocompatibility Antigens Class I Genetics Administration & Dosage Maze Learning Membrane Proteins Mice Mice, Knockout Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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