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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Soares, Ana Prates Do Espírito Santo, Renan Fernandes Line, Sérgio Roberto Peres Pinto, Maria das Graças Farias Santos, Pablo de Moura Toralles, Maria Betânia Pereira Do Espírito Santo, Alexandre Ribeiro |
| Description | Author Affiliation: Soares AP ( Multidisciplinary Institute of Health, Federal University of Bahia - UFBA, Rua Rio de Contas, 58, Quadra 17, Lote 58, Candeias, Vitória da Conquista, BA CEP 45.029-094, Brazil. Electronic address: anapratess@hotmail.com.); do Espírito Santo RF ( Faculty of Pharmacy, Federal University of Bahia - UFBA, Rua Barão de Jeremoabo, S/N, Campus Universitário de Ondina, Ondina, Salvador, BA CEP 40.170-115, Brazil. Electronic address: r.fernandes88@hotmail.com.); Line SR ( Piracicaba Dental School, University of Campinas - UNICAMP, Av. Limeira, 901, Areião, Piracicaba, SP CEP 13.414-903, Brazil. Electronic address: serglin@unicamp.br.); Pinto Md ( School of Veterinary Medicine and Zootechny, Federal University of Bahia - UFBA, Av. Ademar de Barros, 500, Ondina, Salvador, BA CEP 40.170-110, Brazil. Electronic address: pintogra@ufba.br.); Santos Pde M ( Professor Edgard Santos University Hospital, Federal University of Bahia - UFBA, Rua Augusto Viana, S/N, Canela, Salvador, BA CEP 40.110-060, Brazil. Electronic address: pablomoura@ufba.br.); Toralles MB ( Institute of Health Sciences, Federal University of Bahia - UFBA, Av. Reitor Miguel Calmon, S/N, Vale do Canela, Salvador, BA CEP 40.110-902, Brazil. Electronic address: m.toralles@uol.com.br.); do Espírito Santo AR ( Institute of Health Sciences, Federal University of Bahia - UFBA, Av. Reitor Miguel Calmon, S/N, Vale do Canela, Salvador, BA CEP 40.110-902, Brazil. Electronic address: arespiritosanto@ufba.br.) |
| Abstract | Bisphosphonates (BPs) avidly bind to calcium crystals and inhibit osteoclastic bone resorption, making them useful for treatment of skeletal disorders such as osteoporosis, Paget's disease, osteogenesis imperfecta and metastatic bone diseases. BPs therapeutically act by causing toxic effects on osteoclasts or interfering with specific intracellular pathways in those cells. BPs that possess nitrogen in their composition are called nitrogen-containing BPs (NBPs) and include alendronate, pamidronate, risedronate, ibandronate, and zoledronate. Simple BPs or non-NBPs do not have nitrogen in their composition, include etiodronate and clodronate, and were the first to be tested in animals and clinically used. Because BPs may be administered to pregnant women or children during deciduous and permanent teeth development, it is expected that they might disturb tooth eruption and development. A review of current literature on pharmacokinetics, bioavailability, mechanisms of action, and clinical applications of BPs in children, and their effects on tooth eruption and development is presented. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Journal | Environmental Toxicology and Pharmacology |
| Volume Number | 42 |
| e-ISSN | 18727077 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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