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Comparative study of therapeutic response to baclofen vs tolperisone in spasticity.

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Comparative study of therapeutic response to baclofen vs tolperisone in spasticity.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Agarwal, Saurabh Patel, Tejas Shah, Nehal Patel, Bhoomika M.
Description	Author Affiliation: Agarwal S ( Institute of Pharmacy, Nirma University, S.G. Highway, Ahmedabad, 382481, India. Electronic address: srbh.agarwal1@gmail.com.); Patel T ( Sparsh Paediatric Rehabilitation Clinic, Navrangpura, Ahmedabad, 380009, India. Electronic address: tejphysio@yahoo.com.); Shah N ( Divya Physiotherapy clinic, Naroda, Ahmedabad, 382345, India. Electronic address: nehnimi@gmail.com.); Patel BM ( Institute of Pharmacy, Nirma University, S.G. Highway, Ahmedabad, 382481, India. Electronic address: drbhoomikampatel@gmail.com.)
Abstract	BACKGROUND: Spasticity from the upper motor neuron syndrome can result from a variety of conditions affecting the cortex or spinal cord. Some of the more common conditions associated with spasticity include spinal cord injury, cerebral palsy, and post-stroke syndrome. In this study we compared the efficacy and safety of baclofen vs tolperisone in spasticity. One hundred fifty patients with cerebral palsy or post stroke or spinal cord injury associated spasticity were enrolled in present study. Group I comprised of Seventy-five patients receiving baclofen and group II comprised of 75 patients receiving tolperisone. For efficacy measurement 4 evaluation methods were used, 1) Modified Ashworth Scale for muscle tone, 2) Medical research council scale for muscle strength and 3) Barthel Index for functional outcome 4) Coefficient of efficacy. In efficacy evaluation, both groups showed significant improvement in muscle tone, muscle strength and functional outcome at week 6 (Group I, 1.55±0.053, 2.79+0.032, 59.31±1.32; Group II, 1.57±0.053, 3.04±0.032, 73±1.32 respectively). In between the group analysis, there was no significant difference in muscle tone improvement in both the groups after 6 weeks (Group I, 1.055±0.053 vs Group II, 1.57±0.053, p>0.05). Group II showed non-significant but greater improvement in muscle strength (Week 6; Group I, 2.79±0.032 vs Group II, 3.04±0.032, p>0.07). Improvement in functional outcomes was greater in group II as compared to group I (Group I, 59.31±1.32 vs Group II, 73±1.32, p<0.05). Overall efficacy coefficient was greater for group II (3.6) as compared to group I (2.3). Baclofen showed more side effects compared to tolperisone in, asthenia being the most frequent. Tolperisone offers greater improvement in activities of daily living compared to baclofen. Tolperisone is more tolerable drug as compared to baclofen.
File Format	HTM / HTML
ISSN	07533322
Volume Number	87
e-ISSN	19506007
Journal	Biomedicine & Pharmacotherapy
Language	English
Publisher	Elsevier
Publisher Date	2017-03-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Baclofen Therapeutic Use Muscle Relaxants, Central Muscle Spasticity Drug Therapy Tolperisone Adolescent Adult Aged Aged, 80 And Over Cerebral Palsy Child Child, Preschool Female Humans Male Middle Aged Muscle Strength Drug Effects Spinal Cord Injuries Stroke Young Adult Comparative Study Journal Article Randomized Controlled Trial
Content Type	Text
Resource Type	Article
Subject	Medicine Pharmacology

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