NDLI: Anti-diabetic effect of three new norditerpenoid alkaloids in vitro and potential mechanism via PI3K/Akt signaling pathway.

Please wait, while we are loading the content...

Year: 2017 Volume: 89

Year: 2017 Volume: 88

Year: 2017 Volume: 87

Effects of anesthetic and analgesic techniques on cancer metastasis.

Transcriptome analysis of EGFR tyrosine kinase inhibitors resistance associated long noncoding RNA in non-small cell lung cancer.

Euphorbia denticulata Lam.: A promising source of phyto-pharmaceuticals for the development of novel functional formulations.

Recent advances in cardiac regeneration: Stem cell, biomaterial and growth factors.

Marine actinobacteria as a drug treasure house.

Radiolabeled bombesin derivatives for preclinical oncological imaging.

Green tea epigallocatechin 3-gallate alleviates hyperglycemia and reduces advanced glycation end products via nrf2 pathway in mice with high fat diet-induced obesity.

Predictive and prognostic biomarkers in colorectal cancer: A systematic review of recent advances and challenges.

A novel elastic liposome for skin delivery of papain and its application on hypertrophic scar.

Taspine derivative 12k suppressed A549 cell migration through the Wnt/ß-catenin and EphrinB2 signaling pathway.

Antiproliferative activity of Alisol B in MDA-MB-231 cells is mediated by apoptosis, dysregulation of mitochondrial functions, cell cycle arrest and generation of reactive oxygen species.

Regulation of different components from Ophiopogon japonicus on autophagy in human lung adenocarcinoma A549Cells through PI3K/Akt/mTOR signaling pathway.

Aryl hydrocarbon receptor activation modulates CD8 TCR ß IELs and suppression of colitis manifestations in mice.

Riluzole ameliorates learning and memory deficits in Aß25-35-induced rat model of Alzheimer's disease and is independent of cholinoceptor activation.

Anti-diabetic effect of three new norditerpenoid alkaloids in vitro and potential mechanism via PI3K/Akt signaling pathway.

In vivo anti-arthritic efficacy of Camellia sinensis (L.) in collagen induced arthritis model.

Chamomile (Matricaria recutita L.) decoction extract inhibits in vitro intestinal glucose absorption and attenuates high fat diet-induced lipotoxicity and oxidative stress.

Synergistic effects of acarbose and an Oroxylum indicum seed extract in streptozotocin and high-fat-diet induced prediabetic mice.

Capparis spinosa leaves extract: Source of bioantioxidants with nephroprotective and hepatoprotective effects.

Propofol inhibits LPS-induced apoptosis in lung epithelial cell line, BEAS-2B.

Epiisopiloturine hydrochloride, an imidazole alkaloid isolated from Pilocarpus microphyllus leaves, protects against naproxen-induced gastrointestinal damage in rats.

Neonatal anesthetic neurotoxicity: Insight into the molecular mechanisms of long-term neurocognitive deficits.

Berberine ameliorates intrahippocampal kainate-induced status epilepticus and consequent epileptogenic process in the rat: Underlying mechanisms.

Synthesis, properties and biomedical applications of carbon-based quantum dots: An updated review.

Anti-oxidative effects of curcumin on immobilization-induced oxidative stress in rat brain, liver and kidney.

Potent antihyperglycemic and hypoglycemic effect of Tamarix articulata Vahl. in normal and streptozotocin-induced diabetic rats.

The antioxidant role of agomelatine and gallic acid on oxidative stress in STZ induced type I diabetic rat testes.

Effect of the Egyptian propolis on the hepatic antioxidant defense and pro-apoptotic p53 and anti-apoptotic bcl2 expressions in aflatoxin B1 treated male mice.

Contemporary imaging of incidentally discovered adrenal masses.

Synthesis and in vitro photodynamic therapy of chlorin derivative 13 -ortho-trifluoromethyl-phenylhydrazone modified pyropheophorbide-a.

CREB knockdown inhibits growth and induces apoptosis in human pre-B acute lymphoblastic leukemia cells through inhibition of prosurvival signals.

Tinospora cordifolia extract attenuates cadmium-induced biochemical and histological alterations in the heart of male Wistar rats.

The impact of different extracellular matrices on melatonin effect in proliferation and stemness properties of ovarian cancer cells.

The properties of red seaweed (Kappaphycus alvarezii) and its effect on mammary carcinogenesis.

Spectral characterisation, antiviral activities, in silico ADMET and molecular docking of the compounds isolated from Tectona grandis to chikungunya virus.

Dermal/transdermal delivery of small interfering RNA and antisense oligonucleotides- advances and hurdles.

A brief review on the application of nanoparticle enclosed herbal medicine for the treatment of infective endocarditis.

Neuroprotective effects of erythropoietin against sevoflurane-induced neuronal apoptosis in primary rat cortical neurons involving the EPOR-Erk1/2-Nrf2/Bach1 signal pathway.

Ethnomedicine based evaluation of osteoprotective properties of Tinospora cordifolia on in vitro and in vivo model systems.

Protection of male reproductive toxicity in rats exposed to di-n-butyl phthalate during embryonic development by testosterone.

Loss of periplakin expression is associated with the tumorigenesis of colorectal carcinoma.

Effects of the activation of heme oxygenase-1 on hormonal and metabolic changes in rats fed a high-fat diet.

Thiosemicarbazones and Phthalyl-Thiazoles compounds exert antiviral activity against yellow fever virus and Saint Louis encephalitis virus.

Epoxy clerodane diterpene inhibits MCF-7 human breast cancer cell growth by regulating the expression of the functional apoptotic genes Cdkn2A, Rb1, mdm2 and p53.

STARS knockout attenuates hypoxia-induced pulmonary arterial hypertension by suppressing pulmonary arterial smooth muscle cell proliferation.

Potential mechanisms of microRNA-129-5p in inhibiting cell processes including viability, proliferation, migration and invasiveness of glioblastoma cells U87 through targeting FNDC3B.

MicroRNA-202-3p regulates scleroderma fibrosis by targeting matrix metalloproteinase 1.

Hydroxysafflor yellow A cardioprotection in ischemia-reperfusion (I/R) injury mainly via Akt/hexokinase II independent of ERK/GSK-3ß pathway.

Polyphenol rich ethanolic extract from Boerhavia diffusa L. mitigates angiotensin II induced cardiac hypertrophy and fibrosis in rats.

Virgin coconut oil supplementation attenuates acute chemotherapy hepatotoxicity induced by anticancer drug methotrexate via inhibition of oxidative stress in rats.

Inositol hexa phosphoric acid (phytic acid), a nutraceuticals, attenuates iron-induced oxidative stress and alleviates liver injury in iron overloaded mice.

Citrus leaf extract reduces blood pressure and vascular damage in repeatedly heated palm oil diet-Induced hypertensive rats.

Assembling of multifunctional latex-based hybrid nanocarriers from Calotropis gigantea for sustained (doxorubicin) DOX releases.

Knockdown of FOXR2 suppresses the tumorigenesis, growth and metastasis of prostate cancer.

Effects of argan oil on the mitochondrial function, antioxidant system and the activity of NADPH- generating enzymes in acrylamide treated rat brain.

Moringa oleifera, a species with potential analgesic and anti-inflammatory activities.

The effect of Elettaria cardamomum extract on anxiety-like behavior in a rat model of post-traumatic stress disorder.

Golden root: A wholesome treat of immunity.

Rosuvastatin improves myocardial and neurological outcomes after asphyxial cardiac arrest and cardiopulmonary resuscitation in rats.

Dosing-time dependent oxidative effects of an immunosuppressive drug 'Mycophenolate Mofetil' on rat kidneys.

Dietary supplementation of grape seed and skin flour mitigates brain oxidative damage induced by a high-fat diet in rat: Gender dependency.

7-O-Geranylquercetin induces apoptosis in gastric cancer cells via ROS-MAPK mediated mitochondrial signaling pathway activation.

Tumor angiogenesis of SCLC inhibited by decreased expression of FMOD via downregulating angiogenic factors of endothelial cells.

Biological function and mechanism of lncRNA-MEG3 in Tenon's capsule fibroblasts proliferation: By MEG3-Nrf2 protein interaction.

Long non-coding RNA ZFAS1 is an unfavourable prognostic factor and promotes glioma cell progression by activation of the Notch signaling pathway.

Oxidative stress and mRNA expression of acetylcholinesterase in the leukocytes of ischemic patients.

Role of miR-15a in intervertebral disc degeneration through targeting MAP3K9.

Anti-osteoporotic effects of an antidepressant tianeptine on ovariectomized rats.

Inhibition viral RNP and anti-inflammatory activity of coumarins against influenza virus.

In situ morphological assessment of apoptosis induced by Phaleria macrocarpa (Boerl.) fruit ethyl acetate fraction (PMEAF) in MDA-MB-231 cells by microscopy observation.

Tithonia diversifolia saponin-blood lipid interaction and its influence on immune system of normal wistar rats.

Epigenetic modifications and epigenetic based medication implementations of autoimmune diseases.

MiR-451 suppresses proliferation, migration and promotes apoptosis of the human osteosarcoma by targeting macrophage migration inhibitory factor.

Comparative study of therapeutic response to baclofen vs tolperisone in spasticity.

A current perspective on the oncopreventive and oncolytic properties of selective serotonin reuptake inhibitors.

Modulatory effect of vanillic acid on antioxidant status in high fat diet-induced changes in diabetic hypertensive rats.

Biological properties of citral and its potential protective effects against cytotoxicity caused by aspirin in the IEC-6 cells.

Apelin-13 protects rat primary cortical glia-neuron co-culture against pentylenetetrazole-induced toxicity.

Long non-coding RNA UC001kfo promotes hepatocellular carcinoma proliferation and metastasis by targeting -SMA.

In vivo and in silico sedative-hypnotic like activity of 7-methyljuglone isolated from Diospyros lotus L.

Long non-coding RNA CCAT1 promotes human retinoblastoma SO-RB50 and Y79 cells through negative regulation of miR-218-5p.

LncRNA CCAT2 promotes tumorigenesis by over-expressed Pokemon in non-small cell lung cancer.

The hemostatic effect study of Cirsium setosum on regulating 1-ARs via mediating norepinephrine synthesis by enzyme catalysis.

Piperine modulates isoproterenol induced myocardial ischemia through antioxidant and anti-dyslipidemic effect in male Wistar rats.

Magnolin inhibits prostate cancer cell growth in vitro and in vivo.

Curcumin confers neuroprotection against alcohol-induced hippocampal neurodegeneration via CREB-BDNF pathway in rats.

Novel phyto-derivative BRM270 inhibits hepatocellular carcinoma cells proliferation by inducing G2/M phase cell cycle arrest and apoptosis in xenograft mice model.

Paclitaxel-releasing mesenchymal stromal cells inhibit in vitro proliferation of human mesothelioma cells.

Year: 2017 Volume: 86

Year: 2016 Volume: 86

Year: 2016 Volume: 85

Year: 2016 Volume: 84

Year: 2016 Volume: 83

Year: 2016 Volume: 82

Year: 2016 Volume: 81

Year: 2016 Volume: 80

Year: 2016 Volume: 79

Year: 2016 Volume: 78

Year: 2016 Volume: 77

Year: 2015 Volume: 76

Year: 2015 Volume: 75

Year: 2015 Volume: 74

Year: 2015 Volume: 73

Year: 2015 Volume: 72

Year: 2015 Volume: 71

Year: 2015 Volume: 70

Year: 2015 Volume: 69

Year: 2014 Volume: 68

Year: 2013 Volume: 67

Year: 2012 Volume: 66

Year: 2011 Volume: 65

Year: 2010 Volume: 64

Year: 2009 Volume: 63

Year: 2008 Volume: 62

Year: 2007 Volume: 61

Year: 2005 Volume: 59

Anti-diabetic effect of three new norditerpenoid alkaloids in vitro and potential mechanism via PI3K/Akt signaling pathway.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tang, Dan Chen, Qi-Bin Xin, Xue-Lei Aisa, Haji-Akber
Description	Author Affiliation: Tang D ( The Key Laboratory of Plant Resources and Chemistry of Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, People's Republic of China.); Chen QB ( The Key Laboratory of Plant Resources and Chemistry of Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, People's Republic of China); Xin XL ( The Key Laboratory of Plant Resources and Chemistry of Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, People's Republic of China. Electronic addr); Aisa HA ( The Key Laboratory of Plant Resources and Chemistry of Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, People's Republic of China. Electronic addr)
Abstract	Diabetes is a metabolic disease with the characteristic of high blood glucose (hyperglycemia). In our previous study, we found that nigelladines A-C (compounds A-C), three norditerpenoid alkaloids from the seeds of Nigella glandulifera Freyn (Ranunculaceae) exhibited protein of tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro. In the present study, we further investigated their anti-diabetes activities in L6 moytubes and illuminated the mechanisms of action of compounds A-C. Several parameters of glucose metabolism such as glucose consumption, glycogen content and hexokinase activity were increased by compounds A-C. The results suggested that compounds A-C improved glucose metabolism through promoting synthesis of glycogen. Expression of PTP1B protein was inhibited by compounds A-C in L6 moytubes. PI3K-dependent Akt phosphorylation was found to be activated by compounds A-C and completely blocked by wortmannin (a PI3K inhibitor). Moreover, the insulin-mediated induction of insulin receptor substrate-1 (IRS-1) and glycogen synthase kinase-3ß (GSK-3ß) were also suppressed by wortmannin. Western blot results indicated that compounds A-C-induced IRS-1/Akt activation was likely a consequence of PTP1B inhibition. Compounds A-C promoted glycogen synthesis through Akt-mediated GSK3 phosphorylation. Therefore, activation of PI3K/Akt insulin signaling pathway and suppression of PTP1B is the molecular mechanism that contributes to the anti-diabetic effect of compounds A-C in cellular models. The three alkaloids potentially serve as lead compounds for the development of antidiabetic drugs.
File Format	HTM / HTML
ISSN	07533322
Volume Number	87
e-ISSN	19506007
Journal	Biomedicine & Pharmacotherapy
Language	English
Publisher	Elsevier
Publisher Date	2017-03-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Diterpenes Pharmacology Hypoglycemic Agents Nigella Phosphatidylinositol 3-kinases Metabolism Plant Extracts Proto-oncogene Proteins C-akt Animals Cells, Cultured Isolation & Purification Glucose Agonists Rats Seeds Signal Transduction Drug Effects Physiology Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Pharmacology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in