NDLI: Neonatal anesthetic neurotoxicity: Insight into the molecular mechanisms of long-term neurocognitive deficits.

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Neonatal anesthetic neurotoxicity: Insight into the molecular mechanisms of long-term neurocognitive deficits.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yu, Deshui Li, Linji Yuan, Weiguo
Description	Author Affiliation: Yu D ( Department of Anesthesiology, The Second People's Hospital of Yibin, Yibin 644000, Sichuan, PR China. Electronic address: ybanesthesia@sina.com.); Li L ( Department of Anesthesiology, Nanchong Central Hospital, The Second Clinical College of North Sichuan Medical College, Nanchong 637000, Sichuan, PR China.); Yuan W ( Department of Anesthesiology, Nanchong Central Hospital, The Second Clinical College of North Sichuan Medical College, Nanchong 637000, Sichuan, PR China.)
Abstract	Mounting animal studies have demonstrated that almost all the clinically used general anesthetics could induce widespread neuroapoptosis in the immature brain. Alarmingly, some published findings have reported long-term neurocognitive deficits in response to early anesthesia exposure which deeply stresses the potential seriousness of developmental anesthetic neurotoxicity. However, the connection between anesthesia induced neuroapoptosis and subsequent neurocognitive deficits remains controversial. It should be noted that developmental anesthesia related neurotoxicity is not limited to neuroapoptosis. Early anesthesia exposure caused transient suppression of neurogenesis, ultrastructural abnormalities in synapse and alteration in the development of neuronal networks also could contribute to the long-term neurocognitive dysfunction. Understanding the mechanisms of developmental anesthetic neurotoxicity, especially by which anesthesia impairs brain function months after exposure, may lead to development of rational preventive and therapeutic strategies. The focus of present review is on some of those potential mechanisms that have been proposed for anesthesia induced cognitive decline.
File Format	HTM / HTML
ISSN	07533322
Volume Number	87
e-ISSN	19506007
Journal	Biomedicine & Pharmacotherapy
Language	English
Publisher	Elsevier
Publisher Date	2017-03-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Anesthetics Adverse Effects Cognition Disorders Chemically Induced Metabolism Neurotoxicity Syndromes Toxicity Animals Animals, Newborn Apoptosis Drug Effects Physiology Brain Pathology Humans Infant, Newborn Time Factors Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Medicine Pharmacology

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