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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Holth, T. F. Eidsvoll, D. P. Farmen, E. Sanders, M. B. Martínez-Gómez, C. Budzinski, H. Burgeot, T. Guilhermino, L. Hylland, K. |
| Spatial Coverage | North Sea |
| Description | Author Affiliation: Holth TF ( Department of Biosciences, University of Oslo, P.O. Box 1066 Blindern, N-0316 Oslo, Norway. Electronic address: t.f.holth@ibv.uio.no.); Eidsvoll DP ( Department of Biosciences, University of Oslo, P.O. Box 1066 Blindern, N-0316 Oslo, Norway.); Farmen E ( Norwegian Institute for Water Research (NIVA), Gaustadaléen 21, N-0349 Oslo, Norway.); Sanders MB ( CEFAS Weymouth Laboratory, The Nothe, Barrack Road, Weymouth, Dorset DT4 8UB, England, United Kingdom.); Martínez-Gómez C ( Instituto Español de Oceanografía, San Pedro del Pinatar, 30740 Varadero 1, Spain.); Budzinski H ( University of Bordeaux, EPOC/LPTC (UMR 5805 CNRS), 351 crs de la Libération, Talence, France.); Burgeot T ( IFREMER, Unit of Research in Biogeochemistry and Ecotoxicology, Rue de I'lle d'Yeu, BP 21105, 44311 Nantes, France.); Guilhermino L ( CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, Laboratory of Ecotoxicology and Ecology & ICBAS - Institute of Biomedical Sciences of Abel Salazar, Department of Population Studies, Laboratory of Ecotoxicology, University of Porto, Rua dos Bragas 289, 4050-123 Porto, Port); Hylland K ( Department of Biosciences, University of Oslo, P.O. Box 1066 Blindern, N-0316 Oslo, Norway.) |
| Abstract | The aim of this study was to characterize concentration- and time-dependent responses in juvenile Atlantic cod (Gadus morhua) following exposure for one and three weeks to the water-soluble fraction (WAF) of three weathered oils: Arabian Light crude oil (ALC), North Sea crude oil (NSC) and ship-diesel. The sum of polycyclic aromatic hydrocarbons (PAH) in water was highest after one week of exposure and within environmentally relevant concentrations. PAH metabolites in bile confirmed exposure to and uptake of PAHs. Hepatic cytochrome P450 1A (CYP1A) gene expression (mRNA quantification) increased dramatically following exposure to all three oil types (fold-change up to 165) and there was a time lag between gene and protein expression. Hepatic CYP1A protein concentration and ethoxyresorufin-O-deethylase (EROD) activity were more variable among individuals and treatments than gene expression. EROD activity in liver and gills increased in fish exposed to WAF from the two crude oils, but not in fish exposed to WAF from diesel. Exposure to diesel appeared to induce oxidative stress to a greater extent than exposure to crude oils. Other biomarkers (glutathione S-transferases, acetylcholine esterase, vitellogenin) did not appear to respond to the exposure and hence did not discriminate among oils. Biomarker responses in cod after exposure to weathered crude oils and diesel suggested that the CYP1A system and oxidative stress markers have the highest potential for discriminating among different oil types and to monitor the environmental consequences of spills. |
| File Format | HTM / HTML |
| ISSN | 0166445X |
| Volume Number | 154 |
| e-ISSN | 18791514 |
| Journal | Aquatic Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-09-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Biological Markers Analysis Gadus Morhua Physiology Gasoline Toxicity Oxidative Stress Drug Effects Petroleum Water Chemistry Animals Bile Cytochrome P-450 Cyp1a1 Metabolism Gills Humans Liver North Sea Water Pollutants, Chemical Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Aquatic Science |
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