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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Minghetti, Matteo Schnell, Sabine Chadwick, Michael A. Hogstrand, Christer Bury, Nic R. |
| Description | Country affiliation: United kingdom Author Affiliation: Minghetti M ( King's College London, Metals Metabolism Group, Division of Diabetes and Nutritional Sciences, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NH, United Kingdom.); Schnell S ( King's College London, Metals Metabolism Group, Division of Diabetes and Nutritional Sciences, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NH, United Kingdom.); Chadwick MA ( King's College London, Department of Geography, Strand, London WC2R 2LS, United Kingdom.); Hogstrand C ( King's College London, Metals Metabolism Group, Division of Diabetes and Nutritional Sciences, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NH, United Kingdom.); Bury NR ( King's College London, Metals Metabolism Group, Division of Diabetes and Nutritional Sciences, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NH, United Kingdom. Electronic address: nic.bury@kcl.ac.uk.) |
| Abstract | Studies were conducted to assess the feasibility of a primary FIsh Gill Cell culture system (FIGCS) for both laboratory and field based environmental monitoring of rivers known to be affected by metal contamination. FIGCS were exposed in the laboratory and in the field to water from the River Hayle, a metal-contaminated system in Cornwall, United Kingdom. Water chemistry, including transition metal concentrations, changes in transepithelial electrical resistance (TEER), cell viability and the expression of metal responsive genes, metallothionein A and B were measured. FIGCS tolerated river water in the laboratory showing no loss in TEER or cell viability following 24h exposure. The cells also tolerated transport to the field (â¼1000 km and 30 h) and exposure to unfiltered and filtered river water. Metallothionein A and B, a measure of intracellular biologically active metals, expression was induced in the laboratory and field on exposure to water from sites with elevated metal concentrations compared to those sites where metal levels were below water metal Environmental Quality Standards. This demonstrates that FIGCS detects bioreactive metals in river waters on exposure in the laboratory or field and can be used for on-site environmental monitoring as well as investigations into bioavailability and toxicity of contaminant mixtures in natural waters. |
| File Format | HTM / HTML |
| ISSN | 0166445X |
| Volume Number | 154 |
| e-ISSN | 18791514 |
| Journal | Aquatic Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-09-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Environmental Monitoring Methods Gills Cytology Metals Toxicity Rivers Chemistry Water Pollutants, Chemical Analysis Animals Cell Survival Drug Effects Cells, Cultured Electric Impedance Epithelial Cells Gene Expression Regulation Metallothionein Genetics Oncorhynchus Mykiss Great Britain Metabolism Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Aquatic Science |
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