NDLI: Reduced sulfate plasma concentrations in the BTBR T+tf/J mouse model of autism.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Corley, Michael J. Meyza, Ksenia Z. Blanchard, D. Caroline Blanchard, Robert J.
Description	Country affiliation: United States Author Affiliation: Corley MJ ( Department of Psychology, University of Hawaii, Honolulu, HI, USA. mcorley@hawaii.edu)
Abstract	Clinical studies have shown that children diagnosed with autism show abnormal sulfate chemistry, which is critical for cellular and metabolic processes. To determine if the inbred BTBR T+tf/J mouse shows autism-relevant aberrations in sulfate chemistry, the present study examined plasma sulfate concentrations in BTBR T+tf/J, inbred C57BL/6J, and outbred CD-1 mice. Results showed that the BTBR T+tf/J mouse exhibits significantly lower plasma sulfate concentrations in comparison to both C57BL/6J and CD-1 mice. These results suggest that the BTBR mouse shows autism-relevant abnormalities in sulfate chemistry and may serve additional utility in examining the role of sulfate and sulfate-dependent systems in relation to autism-relevant behavioral aberrations.
File Format	HTM / HTML
ISSN	00319384
e-ISSN	1873507X
DOI	10.1016/j.physbeh.2012.04.010
Journal	Physiology & Behavior
Issue Number	5
Volume Number	107
Language	English
Publisher	Elsevier
Publisher Date	2012-12-05
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Research Support, N.i.h., Extramural Autistic Disorder Mice, Inbred C57bl Sulfates Mice, Inbred Strains Blood Discipline Physiology Animals Mice Discipline Behavioral Neuroscience Disease Models, Animal
Content Type	Text
Resource Type	Article
Subject	Experimental and Cognitive Psychology Behavioral Neuroscience

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