NDLI: Corticosteroid and neurosteroid dysregulation in an animal model of autism, BTBR mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Frye, Cheryl A. Llaneza, Danielle C.
Description	Country affiliation: United States Author Affiliation: Frye CA ( Department of Psychology, University at Albany-SUNY, Albany, NY 12222, United States. fryeca@gmail.com)
Abstract	Autism spectrum disorders (ASD) are a constellation of neurodevelopmental disorders associated with disruptions in social, cognitive, and/or motor behaviors. ASD are more prevalent among males than females and characterized by aberrant social and language development, and a dysregulation in stress-responding. Levels of progesterone (P(4)) and its metabolite 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) are higher and more variable in females compared to males. 3alpha,5alpha-THP is also a neurosteroid, which can be rapidly produced de novo in the brain, independent of peripheral gland secretion, and can exert homeostatic effects to modulate stress-responding. An inbred mouse strain that has demonstrated an ASD-like behavioral and neuroendocrine phenotype is BTBR T +tf/J (BTBR). BTBR mice have deficits in cognitive and social behaviors and have high circulating levels of the stress hormone, corticosterone. We hypothesized that central 3alpha,5alpha-THP levels would be different among BTBR mice compared to mice on a similar background C57BL/6J (C57/J) and 129S1/SvlmJ (129S1). Tissues were collected from BTBR, C57/J and 129S1 male mice and levels of corticosterone, P(4), and 3alpha,5alpha-THP in plasma and in the hypothalamus, midbrain, hippocampus, and cerebellum were measured by radioimmunoassay. Circulating levels of corticosterone, P(4), and 3alpha,5alpha-THP were significantly higher among BTBR, than C57/J and 129S1, mice. Levels of P(4) in the cerebellum were significantly higher than other brain regions among all mouse strains. Levels of 3alpha,5alpha-THP in the hypothalamus of BTBR mice were significantly higher compared to C57/J and 129S1 mice. These findings suggest that neuroendocrine dysregulation among BTBR mice extends to 3alpha,5alpha-THP.
File Format	HTM / HTML
ISSN	00319384
e-ISSN	1873507X
DOI	10.1016/j.physbeh.2010.03.005
Journal	Physiology & Behavior
Issue Number	3
Volume Number	100
Language	English
Publisher	Elsevier
Publisher Date	2010-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cerebellum Research Support, N.i.h., Extramural Brain Comparative Study Mesencephalon Corticosterone Hypothalamus Blood Discipline Physiology Radioimmunoassay 5-alpha-dihydroprogesterone Disease Models, Animal Research Support, U.s. Gov't, Non-p.h.s. Autistic Disorder Mice, Inbred C57bl Metabolism Mice, Inbred Strains Neurotransmitter Agents Animals Mice Progesterone Discipline Behavioral Neuroscience Hippocampus
Content Type	Text
Resource Type	Article
Subject	Experimental and Cognitive Psychology Behavioral Neuroscience

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Corticosteroid and Neurosteroid Dysregulation in an Animal Model of Autism, BTBR Mice

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Engaging in paced mating, but neither exploratory, anti-anxiety, nor social behavior, increases 5alpha-reduced progestin concentrations in midbrain, hippocampus, striatum, and cortex.

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Corticosteroid and neurosteroid dysregulation in an animal model of autism, BTBR mice.

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Corticosteroid and Neurosteroid Dysregulation in an Animal Model of Autism, BTBR Mice

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