NDLI: Versatility of the mouse reversal/set-shifting test: effects of topiramate and sex.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bissonette, Gregory B. Lande, Michelle D. Martins, Gabriela J. Powell, Elizabeth M.
Description	Country affiliation: United States Author Affiliation: Bissonette GB ( Department of Anatomy & Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.)
Abstract	The ability to learn a rule to guide behavior is crucial for cognition and executive function. However, in a constantly changing environment, flexibility in terms of learning and changing rules is paramount. Research suggests there may be common underlying causes for the similar rule learning impairments observed in many psychiatric disorders. One of these common anatomical manifestations involves deficits to the GABAergic system, particularly in the frontal cerebral cortical regions. Many common anti-epileptic drugs and mood stabilizers activate the GABA system with the reported adverse side effects of cognitive dysfunction. The mouse reversal/set-shifting test was used to evaluate effects in mice given topiramate, which is reported to impair attention in humans. Here we report that in mice topiramate prevents formation of the attentional set, but does not alter reversal learning. Differences in the GABA system are also found in many neuropsychiatric disorders that are more common in males, including schizophrenia and autism. Initial findings with the reversal/set-shifting task excluded female subjects. In this study, female mice tested on the standard reversal/set-shifting task showed similar reversal learning, but were not able to form the attentional set. The behavioral paradigm was modified and when presented with sufficient discrimination tasks, female mice performed the same as male mice, requiring the same number of trials to reach criterion and form the attentional set. The notable difference was that female mice had an extended latency to complete the trials for all discriminations. In summary, the reversal/set-shifting test can be used to screen for cognitive effects of potential therapeutic compounds in both male and female mice.
File Format	HTM / HTML
ISSN	00319384
e-ISSN	1873507X
DOI	10.1016/j.physbeh.2012.05.018
Journal	Physiology & Behavior
Issue Number	5
Volume Number	107
Language	English
Publisher	Elsevier
Publisher Date	2012-12-05
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Mice, Inbred C57bl Attention Reaction Time Pharmacology Drug Effects Fructose Reversal Learning Discipline Physiology Animals Sex Factors Physiology Mice Discipline Behavioral Neuroscience Analogs & Derivatives Discrimination Learning
Content Type	Text
Resource Type	Article
Subject	Experimental and Cognitive Psychology Behavioral Neuroscience

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