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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yazir, Yusufhan Utkan, Tijen Gacar, Nejat Aricioglu, Feyza |
| Description | Country affiliation: Turkey Author Affiliation: Yazir Y ( Kocaeli University Faculty of Medicine, Department of Histology and Embryology, Kocaeli, Turkey.); Utkan T ( Kocaeli University Faculty of Medicine, Department of Pharmacology, Kocaeli, Turkey); Gacar N ( Kocaeli University Faculty of Medicine, Department of Pharmacology, Kocaeli, Turkey.); Aricioglu F ( Marmara University Faculty of Pharmacy, Department of Pharmacology and Psychopharmacology Unit, Istanbul, Turkey.) |
| Abstract | A number of studies have recently focused on the neuroprotective and anti-inflammatory effects of resveratrol. In prior studies, we described its beneficial effects on scopolamine-induced learning deficits in rats. The aim of this study was to investigate the effects of resveratrol on emotional and spatial cognitive functions, neurotropic factor expression, and plasma levels of proinflammatory cytokines in rats exposed to chronic unpredictable mild stress (CUMS), which is known to induce cognitive deficits. Resveratrol (5 or 20mg/kg) was administered intraperitoneally for 35 days. Rats in the CUMS group and in the 5mg/kg resveratrol+CUMS group performed poorly in tasks designed to assess emotional and spatial learning and memory. The 20mg/kg resveratrol+CUMS group showed improved performance compared to the CUMS group. In addition, the CUMS procedure induced lower expression of brain-derived neurotrophic factor and c-Fos in hippocampal CA1 and CA3 and in the amygdala of stressed rats. These effects were reversed by chronic administration of resveratrol (20mg/kg). In addition, plasma levels of tumor necrosis factor-alpha and interleukin-1 beta were increased by CUMS, but were restored to normal by resveratrol. These results indicate that resveratrol significantly attenuates the deficits in emotional learning and spatial memory seen in chronically stressed rats. These effects may be related to resveratrol-mediated changes in neurotrophin factor expression in hippocampus and in levels of proinflammatory cytokines in circulation. |
| File Format | HTM / HTML |
| ISSN | 00319384 |
| Volume Number | 138 |
| e-ISSN | 1873507X |
| Journal | Physiology & Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Neuroprotective Agents Uncertainty Amygdala Rats, Wistar Male Blood Journal Article Discipline Physiology Stilbenes Spatial Learning Anti-inflammatory Agents Dose-response Relationship, Drug Brain-derived Neurotrophic Factor Physiology Disease Models, Animal Proto-oncogene Proteins C-fos Prevention & Control Complications Drug Therapy Injections, Intraperitoneal Pharmacology Interleukin-1beta Metabolism Drug Effects Tumor Necrosis Factor-alpha Emotions Physiopathology Memory Disorders Animals Stress, Psychological Spatial Memory Chronic Disease Discipline Behavioral Neuroscience Hippocampus |
| Content Type | Text |
| Resource Type | Article |
| Subject | Experimental and Cognitive Psychology Behavioral Neuroscience |
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